您的位置：首页 > 产品中心 > Surfen hydrate
Surfen hydrate
产品别名
Surfen hydrate
Aminokinuride
Aminoquinuride
1,3-Bis(4-amino-2-methyl-6-quinolyl)urea hydrate
N,N′-Bis(4-amino-2-methyl-6-quinolyl)urea
Aminoquincarbamide
NSC 12155
(bis-2-methyl-4-amino-quinolyl-6-carbamide hydrate
结构式
基本信息
| Empirical Formula【经验(实验)分子式】 | C21H20N6O · xH2O |
| Molecular weight | 372.42 (anhydrous basis) |
| MDL number | MFCD17215963 |
| PubChem Substance ID【PubChem化学物质编号】 | 329824572 |
| NACRES | NA.77 |
| Application【应用】 | Surfen hydrate may be used as an antagonist to heparin. Surfen hydrate has been used in the inhibition of multiple voltage-gated calcium channels in human embryonic kidney cells. |
| Biochem/physiol Actions【生化/生理作用】 | Surfen is a heparan sulfate antagonist, originally developed in the late thirties as an excipient for the production of depot insulin. Heparan sulfate (HS) is structurally related to heparin but contains fewer sulfate groups per disaccharide, and it exists almost exclusively attached to protein cores of proteoglycans, which cells either display on the plasma membrane or secrete into the extracellular matrix. Surfen binds to the chains of glycosaminoglycan (GAG)/HS and prevents binding of the enzymes and proteins thus act as HS antagonist. Surfen is more potent than protamine, a clinically used heparin antagonist. |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥98% (HPLC) |
| form【形式】 | powder |
| color【颜色】 | white to beige |
| solubility【溶解性】 | DMSO: 2 mg/mL, clear |
| storage temp.【储存温度】 | 2-8℃ |
| SMILES string | O.Cc1cc(N)c2cc(NC(=O)Nc3ccc4nc(C)cc(N)c4c3)ccc2n1 |
| InChI | 1S/C21H20N6O.H2O/c1-11-7-17(22)15-9-13(3-5-19(15)24-11)26-21(28)27-14-4-6-20-16(10-14)18(23)8-12(2)25-20;/h3-10H,1-2H3,(H2,22,24)(H2,23,25)(H2,26,27,28);1H2 |
| InChI key | UXYZYUHSZVKWTR-UHFFFAOYSA-N |
| packaging【包装】 | 5, 25 mg in glass bottle |
安全信息
| Hazard Statements | H413 |
| Hazard Classifications【危险分类】 | Aquatic Chronic 4 |
| Storage Class Code【储存分类代码】 | 13 - Non Combustible Solids |
| WGK | WGK 3 |
