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TN-16
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| 产品编号 | 包装单位 | 单价(元) | 国内现货 | 国外库存 | 询价单 |
| 3253401 | 5 MG | 1650 | |||
| 3253401 | 25 MG | 6080 |
产品别名
33016-12-5
TN-16
3-[1-(Phenylamino)ethylidene]-5-(phenylmethyl)-2,4-pyrrolidinedione
NSC 239274
结构式
基本信息
| Empirical Formula【经验(实验)分子式】 | C19H18N2O2 |
| Molecular weight | 306.36 |
| PubChem Substance ID【PubChem化学物质编号】 | 329826871 |
| NACRES | NA.77 |
| Application【应用】 | TN-16 has been used as a microtubule disrupting agent to study its effect on autophagic process in human and mouse mammary carcinoma cell lines . |
| Biochem/physiol Actions【生化/生理作用】 | 3-(l-anilinoethylidene)-5-benzylpyrrolidine-2,4-dione (TN-16), a tenuazonic acid derivative, is a synthetic antitumor agent which arrests mitosis of tumor cells at metaphase. It is a colchicine site binding agent and a powerful autophagy flux inhibitor that could be used as a conventional autophagy inhibitor with anti-cancer potential in pre-clinical trials. TN-16 is a synthetic compound that blocks the assembly, and promotes the dissociation of microtubules. It can prevent the b-TrCP-mediated degradation of the transcription factor Gli2, leading to the up-regulation of BMP-2 and supporting a role for microtubule formation in the regulation of bone formation. Inhibitor of microtubule assembly |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥98% (HPLC) |
| form【形式】 | powder |
| color【颜色】 | white to tan |
| solubility【溶解性】 | DMSO: ≥17 mg/mL |
| storage temp.【储存温度】 | 2-8℃ |
| SMILES string | C\C(Nc1ccccc1)=C2\C(=O)NC(Cc3ccccc3)C2=O |
| InChI | 1S/C19H18N2O2/c1-13(20-15-10-6-3-7-11-15)17-18(22)16(21-19(17)23)12-14-8-4-2-5-9-14/h2-11,16,20H,12H2,1H3,(H,21,23)/b17-13- |
| InChI key | KWSXUGYAGMSUTN-LGMDPLHJSA-N |
| packaging【包装】 | 5, 25 mg in glass bottle |
安全信息
| Pictograms【象形图】 | GHS07,GHS09 |
| Signal word【警示用语：】 | Warning |
| Hazard Statements | H317 - H400 |
| Precautionary Statements | P273 - P280 - P302 + P352 |
| Hazard Classifications【危险分类】 | Aquatic Acute 1 - Skin Sens. 1 |
| Storage Class Code【储存分类代码】 | 11 - Combustible Solids |
| WGK | WGK 3 |
