Tocainide 盐酸盐

C₁₁H₁₆N₂O · HCl

228.72

275-361-2

MFCD00941502

24724626

NA.77

Tocainide hydrochloride may be used in cell signaling studies.

Tocainide hydrochloride is a primary amine analog of lidocaine (lignocaine), used for the treatment of tinnitus. It blocks the sodium channels in the pain-producing foci in the nerve membranes and renders an analgesic effect in trigeminal neuralgia.
Tocainide hydrochloride is a sodium channel blocker; Class IB antiarrhythmic.

This compound was developed by AstraZeneca. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
Tocainide is voltage-dependent and use-dependent sodium channel blocker (class IB type antiarrhythmic); K_i = 115 μM in blockade of inactivated-state sodium channels; IC₅₀ = 985μM in blockade of Na+ currents at a holding potential (HP) of -140 mV; IC₅₀ = 254 μM in blockade of Na+ currents at HP -70 mV; IC₅₀ = 523 μM in blockade of Na+ currents at tonic block (-100 mV); IC₅₀ = 248 μM for use-dependent block at 10 Hz.

100

≥98% (HPLC)

solid

desiccated
under inert gas

white

DMSO: >20 mg/mL
H₂O: ≥5 mg/mL

AstraZeneca

2-8℃

Cl[H].CC(N)C(=O)Nc1c(C)cccc1C

1S/C11H16N2O.ClH/c1-7-5-4-6-8(2)10(7)13-11(14)9(3)12;/h4-6,9H,12H2,1-3H3,(H,13,14);1H

AMZACPWEJDQXGW-UHFFFAOYSA-N

human ... SCN10A(6336), SCN11A(11280), SCN1A(6323), SCN2A(6326), SCN3A(6328), SCN4A(6329), SCN5A(6331), SCN7A(6332), SCN8A(6334), SCN9A(6335)

10, 50 mg in glass bottle

GHS07

Warning

H302

Acute Tox. 4 Oral

13 - Non Combustible Solids

WGK 3

dust mask type N95 (US), Eyeshields, Gloves