Torsemide

C₁₆H₂₀N₄O₃S

348.42

MFCD00866166

329826741

NA.77

Torsemide has been used as an inhibitor of Na⁺ Cl^- co-transporter in transgenic Arabidopsis thaliana plants¹.

Torsemide is a loop diuretic of the pyridine-sulfonylurea class with antialdosteronergic properties and inhibitor of the Na⁺/K⁺/2Cl^- carrier system.
Torsemide functions in the thick ascending limb of the loop of Henle and enhances the excretion of sodium, chloride and water from the luminal side of the cells. Furthermore, torsemide can treat oedematous conditions that are associated with diseases such as liver cirrhosis, kidney disorders and chronic congestive heart failure².

This compound was developed by Roche. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Torsemide is soluble in DMSO at 18 mg/ml and is insoluble in water.

Tandem Mass Spectrometry data independently generated by Scripps Center for Metabolomics is available to view or download in PDF. T3202.pdf Tested metabolites are featured on Scripps Center for Metabolomics METLIN Metabolite Database. To learn more, visit sigma.com/metlin.

100

≥98% (HPLC)

solid

DMSO: soluble 18 mg/mL
H₂O: insoluble

Roche

CC(C)NC(=O)NS(=O)(=O)c1cnccc1Nc2cccc(C)c2

1S/C16H20N4O3S/c1-11(2)18-16(21)20-24(22,23)15-10-17-8-7-14(15)19-13-6-4-5-12(3)9-13/h4-11H,1-3H3,(H,17,19)(H2,18,20,21)

NGBFQHCMQULJNZ-UHFFFAOYSA-N

human ... SLC12A1(6557)

10, 50 mg in glass bottle

GHS07,GHS08

Warning

H319 - H361fd

P201 - P202 - P264 - P280 - P305 + P351 + P338 - P308 + P313

Eye Irrit. 2 - Repr. 2

11 - Combustible Solids

WGK 2

dust mask type N95 (US), Eyeshields, Gloves