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Tyr-Ile-Gly-Ser-Arg
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| 产品编号 | 包装单位 | 单价(元) | 国内现货 | 国外库存 | 询价单 |
| 3257592 | 1 MG | 1710 | |||
| 3257592 | 5 MG | 5230 |
产品别名
110590-64-2
Tyr-Ile-Gly-Ser-Arg
Laminin Fragment 929-933
结构式
基本信息
| Empirical Formula【经验(实验)分子式】 | C26H42N8O8 |
| Molecular weight | 594.66 |
| MDL number | MFCD00076472 |
| PubChem Substance ID【PubChem化学物质编号】 | 24900419 |
| NACRES | NA.32 |
| Amino Acid Sequence | Tyr-Ile-Gly-Ser-Arg |
| Application【应用】 | Tyr-Ile-Gly-Ser-Arg (YIGSR) can be used at the interface between the conjugated polymer and the tissue for the engineering of tissue interface. The product can also be used to study the role of integrins β1, α6, and α3 in promoting type II epithelial differentiation during lung maturation in the fetus. |
| Biochem/physiol Actions【生化/生理作用】 | Tyr-Ile-Gly-Ser-Arg (YIGSR) is a pentapeptide of the protein laminin that reduces the lung colony formation in mice administered with melanoma cells as well as can block the invasiveness of the cells in vitro. It inhibits the increased expression of endothelial nitric-oxide synthase in primary porcine aortic endothelial cells. Tyr-Ile-Gly-Ser-Arg is a fragment of domain III of the laminin B1 chain . It is a major receptor binding site in laminin. It competes with laminin for the cell surface receptor. It is an inhibitor of tumor growth and metastasis. |
| Preparation Note【制备说明】 | Tyr-Ile-Gly-Ser-Arg dissolves in water at 1 mg/ml to yield a clear, colorless solution. |
产品性质
| Quality Level【质量水平】 | 200 |
| biological source【生物来源】 | synthetic (organic) |
| Assay【测定】 | ≥97% (HPLC) |
| form【形式】 | powder |
| technique(s) | cell culture | mammalian: suitable |
| solubility【溶解性】 | H2O: soluble 1 mg/mL, clear, colorless |
| storage temp.【储存温度】 | −20℃ |
| SMILES string | CC[C@H](C)[C@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O |
| InChI | 1S/C26H42N8O8/c1-3-14(2)21(34-22(38)17(27)11-15-6-8-16(36)9-7-15)24(40)31-12-20(37)32-19(13-35)23(39)33-18(25(41)42)5-4-10-30-26(28)29/h6-9,14,17-19,21,35-36H,3-5,10-13,27H2,1-2H3,(H,31,40)(H,32,37)(H,33,39)(H,34,38)(H,41,42)(H4,28,29,30)/t14-,17-,18-,19-,21-/m0/s1 |
| InChI key | MWOGMBZGFFZBMK-LJZWMIMPSA-N |
安全信息
| Storage Class Code【储存分类代码】 | 13 - Non Combustible Solids |
| WGK | WGK 3 |
| Personal Protective Equipment【个人防护装备】 | Eyeshields, Gloves, type N95 (US) |
