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VU0357017 monohydrochloride
产品别名
1135242-13-5
VU0357017 monohydrochloride
CID 25010775
ML071 hydrochloride
4-[[2-[(2-Methylbenzoyl)amino]ethyl]amino]-1-piperidinecarboxylic acid ethyl ester monohydrochloride
SID 56353039
结构式
基本信息
| Empirical Formula【经验(实验)分子式】 | C18H27N3O3 · HCl |
| Molecular weight | 369.89 |
| MDL number | MFCD17215959 |
| PubChem Substance ID【PubChem化学物质编号】 | 329829053 |
| NACRES | NA.77 |
| Biochem/physiol Actions【生化/生理作用】 | VU0357017 is a subtype-selective M1 muscarinic acetylcholine allosteric agonist. VU0357017 has a potency of 200 nM and Achmax of 81% and had no activity at M2-M5 up to the highest concentrations tested and also had little or no detectable antagonist activity at any other mAChR subtype at concentrations over 2 orders of magnitude higher than those required to activate M1 or activity at a large panel of GPCRs, ion channels, and transporters. In contrast, TBPB inhibited responses to ACh at each of the other mAChR subtypes. VU0357017 was active in reversing cognitive deficits induced by scopolamine in a preclinical rodent model. |
| Features and Benefits【特点和优势】 | This compound is featured on the Acetylcholine Receptors (Muscarinic) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here. |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥98% (HPLC) |
| form【形式】 | powder |
| color【颜色】 | white to off-white |
| solubility【溶解性】 | DMSO: ≥10 mg/mL |
| storage temp.【储存温度】 | 2-8℃ |
| SMILES string | Cl.CCOC(=O)N1CCC(CC1)NCCNC(=O)c2ccccc2C |
| InChI | 1S/C18H27N3O3.ClH/c1-3-24-18(23)21-12-8-15(9-13-21)19-10-11-20-17(22)16-7-5-4-6-14(16)2;/h4-7,15,19H,3,8-13H2,1-2H3,(H,20,22);1H |
| InChI key | XKJQVUIXSBOCPP-UHFFFAOYSA-N |
| packaging【包装】 | 5, 25 mg in glass bottle |
安全信息
| Storage Class Code【储存分类代码】 | 11 - Combustible Solids |
| WGK | WGK 2 |
