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XL413 hydrochloride
产品别名
1169562-71-3
XL413 hydrochloride
BMS-863233
(S)-8-Chloro-2-(pyrrolidin-2-yl)benzofuro[3,2-d]pyrimidin-4(3H)-one hydrochloride
XL-413
结构式
基本信息
| Empirical Formula【经验(实验)分子式】 | C14H12ClN3O2 · xHCl |
| Molecular weight | 289.72 (free base basis) |
| PubChem Substance ID【PubChem化学物质编号】 | 329825849 |
| NACRES | NA.77 |
| Biochem/physiol Actions【生化/生理作用】 | XL413 is a selective inhibitor of the serine-threonine kinase CDC7 (cell division cycle 7 homolog), a regulator of cell cycle checkpoint control that has been implicated in protecting tumor cells from apoptotic cell death during replication stress. XL413 has an IC50 of 3.4 nM for CDC7, compared to 215 nM, 42 nM and 18 nM for CK2, PIM1 and pMCM2, respectively. XL413 caused significant tumor growth regression in rodent models, causing cell cycle arrest in the late S to G2 phase. |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥98% (HPLC) |
| form【形式】 | powder |
| storage condition【储存条件】 | desiccated |
| color【颜色】 | white to beige |
| solubility【溶解性】 | H2O: 5 mg/mL, clear |
| storage temp.【储存温度】 | −20℃ |
| SMILES string | ClC1=CC2=C(C=C1)OC3=C2N=C([C@H]4NCCC4)NC3=O.C |
| InChI | 1S/C14H12ClN3O2.CH4/c15-7-3-4-10-8(6-7)11-12(20-10)14(19)18-13(17-11)9-2-1-5-16-9;/h3-4,6,9,16H,1-2,5H2,(H,17,18,19);1H4/t9-;/m0./s1 |
| InChI key | UYBMDYGAVMHMGF-FVGYRXGTSA-N |
| packaging【包装】 | 5, 25 mg in glass bottle |
安全信息
| Pictograms【象形图】 | GHS06 |
| Signal word【警示用语：】 | Danger |
| Hazard Statements | H301 |
| Precautionary Statements | P301 + P310 + P330 |
| Hazard Classifications【危险分类】 | Acute Tox. 3 Oral |
| Storage Class Code【储存分类代码】 | 6.1D - Non-combustible, acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects |
| WGK | WGK 3 |
