Z-Phe-Ala fluoromethyl ketone

C₂₁H₂₃N₂O₄F

386.42

MFCD00883668

329774889

NA.77

Z-Phe-Ala fluoromethyl ketone (Z-FA-FMK) has been used as a:

• cathepsin inhibitor to study its effects on dendritic cells
• papain-like cysteine protease inhibitor to study its effects on cadmium-induced mitochondrial apoptosis
• cysteine protease inhibitor to study its effects on the interaction of toll-like receptor 9 (TLR9) with granulin in RAW macrophages

Z-Phe-Ala fluoromethyl ketone (Z-FA-FMK) is an inhibitor of cysteine proteases, such as cathepsin B and L. It can also inhibit recombinant effector caspases 2, -3, -6, and -7 and not initiator caspases 8 and -10. Z-FA-FMK plays a role in blocking nuclear factor κ-light-chain-enhancer of activated B cells (NF-κB) transactivation. It exhibits therapeutic effects against rheumatoid arthritis.

200

≥90% (TLC)

powder

white to off-white

DMSO or DMF: 20 mM

dry ice

−20℃

C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)OCc2ccccc2)C(=O)CF

1S/C21H23FN2O4/c1-15(19(25)13-22)23-20(26)18(12-16-8-4-2-5-9-16)24-21(27)28-14-17-10-6-3-7-11-17/h2-11,15,18H,12-14H2,1H3,(H,23,26)(H,24,27)/t15-,18-/m0/s1

ASXVEBPEZMSPHB-YJBOKZPZSA-N

13 - Non Combustible Solids

WGK 3

Eyeshields, Gloves, type N95 (US)