您的位置：首页 > 产品中心 > ZK 200775 hydrate
ZK 200775 hydrate
产品别名
ZK 200775 hydrate
[[3,4-Dihydro-7-(4-morpholinyl)-2,3-dioxo-6-(trifluoromethyl)-1(2H)-quinoxalinyl]methyl]-phosphonic acid hydrate
MPQX
Fanapanel
结构式
基本信息
| Empirical Formula【经验(实验)分子式】 | C14H15F3N3O6P · xH2O |
| Molecular weight | 409.25 (anhydrous basis) |
| MDL number | MFCD18452859 |
| PubChem Substance ID【PubChem化学物质编号】 | 329831618 |
| NACRES | NA.77 |
| General description【一般描述】 | ZK 200775 is a selective AMPA/kainite receptor antagonist with very low affinity for NMDA associated binding sites (Ki for CNQX binding site = 32 nM vs. 2.8 uM for DCKA binding site.) ZK 200775 displays superior PK and safety profiles in in vivo studies compared to quinoxalinedione antagonists such as NBQX, showing no effects on motor behavior or cardiac events at efficacious doses in rat. Additionally, unlike other quinoxalinediones, ZK 200775 is water soluble, making this a desirable tool compound for in vivo studies. |
| Features and Benefits【特点和优势】 | This compound is featured on the Glutamate Receptors (Ion Channel Family) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here. |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥98% (HPLC) |
| form【形式】 | powder |
| color【颜色】 | off-white to light brown |
| solubility【溶解性】 | DMSO: ≥20 mg/mL |
| storage temp.【储存温度】 | 2-8℃ |
| SMILES string | O.OP(O)(=O)CN1C(=O)C(=O)Nc2cc(c(cc12)N3CCOCC3)C(F)(F)F |
| InChI | 1S/C14H15F3N3O6P.H2O/c15-14(16,17)8-5-9-11(6-10(8)19-1-3-26-4-2-19)20(7-27(23,24)25)13(22)12(21)18-9;/h5-6H,1-4,7H2,(H,18,21)(H2,23,24,25);1H2 |
| InChI key | RYQLMFHPDNKPKY-UHFFFAOYSA-N |
| packaging【包装】 | 10, 50 mg in glass bottle |
安全信息
| Storage Class Code【储存分类代码】 | 11 - Combustible Solids |
| WGK | WGK 3 |
