(R)-(+)-氨鲁米特

C₁₃H₁₆N₂O₂

232.28

24878857

NA.22

(R)-(+)-Aminoglutethimide can be used:

• As a building block for the development of cephalosporin based prodrug for antibody-directed enzyme prodrug therapy (ADEPT).
• To prepare (R)-3-ethyl-3-(4-(3,4,5-trimethoxybenzylamino)phenyl)piperidine-2,6-dione by reacting with 3,4,5-trimethoxybenzylamine via deaminative coupling reaction.
• To synthesize (R)-2-fluoro-2-(4-methoxyphenyl)-N-(R)-(+)-aminoglutethimide by enantioselective α-fluorination.

100

97%

[α]20/D +160°, c = 1 in methanol

115.5-119.5 ℃ (lit.)

CC[C@@]1(CCC(=O)NC1=O)c2ccc(N)cc2

1S/C13H16N2O2/c1-2-13(8-7-11(16)15-12(13)17)9-3-5-10(14)6-4-9/h3-6H,2,7-8,14H2,1H3,(H,15,16,17)/t13-/m1/s1

ROBVIMPUHSLWNV-CYBMUJFWSA-N

human ... CYP17A1(1586), CYP19A1(1588)

500 mg in amber glass bottle

GHS07

Warning

H315 - H319 - H335

P302 + P352 - P305 + P351 + P338

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Respiratory system

11 - Combustible Solids

WGK 3

dust mask type N95 (US), Eyeshields, Gloves