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6,8-Bis(benzylthio)-octanoic acid
产品价格查看更多规格...
| 产品编号 | 包装单位 | 单价(元) | 国内现货 | 国外库存 | 询价单 |
| 3327882 | 5 MG | 1380 | |||
| 3327882 | 25 MG | 5070 |
产品别名
95809-78-2
6,8-Bis(benzylthio)-octanoic acid
6,8-Bis[(phenylmethyl)thio-octanoic acid
CPI-613
结构式
基本信息
| Empirical Formula【经验(实验)分子式】 | C22H28O2S2 |
| Molecular weight | 388.59 |
| MDL number | MFCD22420826 |
| PubChem Substance ID【PubChem化学物质编号】 | 329825400 |
| NACRES | NA.77 |
| Application【应用】 | 6,8-Bis(benzylthio)-octanoic acid has been used as pyruvate dehydrogenase (PDH) inhibitor:
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| Biochem/physiol Actions【生化/生理作用】 | 6,8-Bis(benzylthio)-octanoic acid (CPI-613) is a lipoate analog. It acts as a mitochondrial disrupter by blocking the mitochondrial enzymes pyruvate dehydrogenase and α-ketoglutarate dehydrogenase. 6,8-Bis(benzylthio)-octanoic acid is an E1α pyruvate dehydrogenase (PDH) modulator that prevents cancer cells from metabolizing glucose for energy. 6,8-Bis(benzylthio)-octanoic acid has been granted orphan drug status by the US FDA for pancreatic cancer. |
| Other Notes【其他说明】 | Air Sensitive |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥98% (HPLC) |
| form【形式】 | powder |
| color【颜色】 | white to beige |
| solubility【溶解性】 | DMSO: 15 mg/mL (clear solution) |
| storage temp.【储存温度】 | 2-8℃ |
| SMILES string | OC(=O)CCCCC(CCSCc1ccccc1)SCc2ccccc2 |
| InChI | 1S/C22H28O2S2/c23-22(24)14-8-7-13-21(26-18-20-11-5-2-6-12-20)15-16-25-17-19-9-3-1-4-10-19/h1-6,9-12,21H,7-8,13-18H2,(H,23,24) |
| InChI key | ZYRLHJIMTROTBO-UHFFFAOYSA-N |
| packaging【包装】 | 5, 25 mg in glass bottle |
安全信息
| Pictograms【象形图】 | GHS09 |
| Signal word【警示用语：】 | Warning |
| Hazard Statements | H410 |
| Precautionary Statements | P273 - P501 |
| Hazard Classifications【危险分类】 | Aquatic Acute 1 - Aquatic Chronic 1 |
| Storage Class Code【储存分类代码】 | 13 - Non Combustible Solids |
| WGK | WGK 3 |
