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6-(5H)-菲啶酮

6-(5H)-Phenanthridinone
产品编号:3328536
规格:technical grade
CAS NO:1015-89-0
包装规格:1 G
产品类别:进口试剂
品牌:Sigma-Aldrich
优惠价:立即咨询
产品编号包装单位单价(元)国内现货国外库存询价单
33285361 G370
产品别名

1015-89-0

6-(5H)-菲啶酮

6-(5H)-Phenanthridinone

NSC 11021

NSC 40943

NSC 61083

结构式
基本信息
Empirical Formula【经验(实验)分子式】
C13H9NO
Molecular weight
195.22
EC number【EC 号】
213-804-3
MDL number
MFCD00004988
PubChem Substance ID【PubChem化学物质编号】
24858050
NACRES
NA.22
General description【一般描述】
6-(5H)-Phenanthridinone is an inhibitor of poly(ADP-ribose)polymerase (PARP)-1 activity. The ability of 6-(5H)-phenanthridinone to potentiate the effect of ionizing radiation on tumour cells was evaluated. Action of 6-(5H)-phenanthridinone, one of the most potent PARP inhibitor, on RDM4 murine lymphoma cells in culture was evaluated.
Application【应用】
Reactant involved in:
  • Synthesis of 5,6-dihydrophenanthridine sulfonamides
  • Oxidative coupling with diphenylacetylene
  • Direct copper acetate-catalyzed N-cyclopropylation of cyclic amides

Reactant involved in the synthesis and/or pharmacological activity of biologically active molecules including:
  • Potassium channel KV1.3 and IK-1 inhibitors
  • HIV-1 integrase inhibitors
产品性质
grade【等级】
technical grade
Quality Level【质量水平】
100
mp
290-292 ℃ (lit.)
SMILES string
O=C1Nc2ccccc2-c3ccccc13
InChI
1S/C13H9NO/c15-13-11-7-2-1-5-9(11)10-6-3-4-8-12(10)14-13/h1-8H,(H,14,15)
InChI key
RZFVLEJOHSLEFR-UHFFFAOYSA-N
Gene Information
human ... PARP1(142)
packaging【包装】
1 g in glass bottle
安全信息
Storage Class Code【储存分类代码】
13 - Non Combustible Solids
WGK
WGK 3
Personal Protective Equipment【个人防护装备】
Eyeshields, Gloves, type N95 (US)
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