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(±)-6-Chloro-PB hydrobromide
产品别名
71636-61-8
(±)-6-Chloro-PB hydrobromide
(±)-6-Chloro-7,8-dihydroxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrobromide
(±)-SKF-81297 hydrobromide
结构式
基本信息
| Empirical Formula【经验(实验)分子式】 | C16H16ClNO2 · HBr |
| Molecular weight | 370.67 |
| MDL number | MFCD00153782 |
| PubChem Substance ID【PubChem化学物质编号】 | 24277934 |
| NACRES | NA.77 |
| Application【应用】 | (±)-6-Chloro-PB hydrobromide has been used as a dopamine D1 receptor (Drd1a) agonist to study the role of the drd1a-dopamine receptor inactivation of extracellular signal‑regulated protein kinase 1/2 (ERK1/2) in the wild-type and striatum of dopamine-depleted mice. It has also been used as a Drd1a agonist to identify the contribution of D1 (D1R)-like dopamine receptor signaling on learning and memory in Barnes maze in rats. |
| Biochem/physiol Actions【生化/生理作用】 | (+/-)-6-Chloro-PB HBr is a full D1 dopamine receptor agonist. |
| Caution【注意】 | Product is air and light sensitive |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥98% (HPLC) |
| form【形式】 | solid |
| color【颜色】 | white to light tan |
| solubility【溶解性】 | H2O: 1.7 mg/mL DMSO: >10 mg/mL ethanol: 6.3 mg/mL |
| SMILES string | Br[H].Oc1cc2C(CNCCc2c(Cl)c1O)c3ccccc3 |
| InChI | 1S/C16H16ClNO2.BrH/c17-15-11-6-7-18-9-13(10-4-2-1-3-5-10)12(11)8-14(19)16(15)20;/h1-5,8,13,18-20H,6-7,9H2;1H |
| InChI key | RMIJGBMRNYUZRG-UHFFFAOYSA-N |
| Gene Information | human ... DRD1(1812) |
| packaging【包装】 | 25, 100 mg in glass bottle |
安全信息
| Pictograms【象形图】 | GHS07 |
| Signal word【警示用语：】 | Warning |
| Hazard Statements | H315 - H319 - H335 |
| Precautionary Statements | P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338 |
| Hazard Classifications【危险分类】 | Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3 |
| Target Organs【靶器官】 | Respiratory system |
| Storage Class Code【储存分类代码】 | 11 - Combustible Solids |
| WGK | WGK 3 |
| Personal Protective Equipment【个人防护装备】 | dust mask type N95 (US), Eyeshields, Gloves |
