α-(Methylamino)isobutyric acid

CH₃NHC(CH₃)₂COOH

117.15

1746984

219-898-2

MFCD00004191

24896726

NA.26

α-(Methylamino)isobutyric acid (MeAIB) has been used:

• as a system A transport system inhibitor to perform inhibition experiments
• as a system A transport system inhibitor to study its effect on the generation of epileptiform field potentials (EFPs) in the acutely disinhibited cortical slices
• as an N-acetyltransferase (SNAT) inhibitor in Hank′s balanced salt solution (HBSS) to study its influence on the uptake of ¹⁴C-cysteine/ radioactive-labeled cysteine

α-(Methylamino)isobutyric acid (MeAIB), a competitive inhibitor of the neutral amino acid transport A system, is an N-methylated substrate. It is capable of decreasing the amplitude of the miniature excitatory postsynaptic current (mEPSC) in hippocampus neurons developing on top of astrocytes. MeAIB can block the alanine-proline (AP) pathway.

100

≥97% (titration)

powder

ligand binding assay: suitable

white

>300 ℃ (lit.)

−20℃

CNC(C)(C)C(O)=O

1S/C5H11NO2/c1-5(2,6-3)4(7)8/h6H,1-3H3,(H,7,8)

DLAMVQGYEVKIRE-UHFFFAOYSA-N

250 mg in poly bottle
1 g in poly bottle

GHS07

Warning

H319

P305 + P351 + P338

Eye Irrit. 2

11 - Combustible Solids

WGK 3

dust mask type N95 (US), Eyeshields, Gloves