A-350619 hydrochloride

C₂₁H₂₅ClN₂OS · HCl

425.41

MFCD06798332

NA.77

Guanylyl cyclases are signal transduction enzyme that convert GTP to cyclic GMP. Soluble guanylate cyclase is activated by a gaseous ligand, nitric oxide.. The nitric oxide activation of soluble guanylate, resulting in GTP conversion to GMP, is important in physiological processes such as as smooth muscle relaxation, neurotransmission, inhibition of platelet aggregation and immune response. A-350619 is an activator of soluble guanylyl cyclase.

A-350619 relaxes cavernosum tissue strips in a dose dependent manner with EC₅₀ of 80 μMM. Because A-350619 at 1 μMmol/kg induces penile erection in a conscious rat model, it may be useful as an alternate method of enhancing the effect of nitric oxide for the treatment of sexual dysfunction.

A-350619 modulates catalytic properties of soluble guanylyl cyclase; it increases V_mas from 0.1 to 14.5 μmol/min/mg and lowers K_m from 300 to 50 μM. A-350619 activation of soluble guanylate cyclase depends on the presence of a heme moiety in the enzyme and synergy with nitric oxide.

This compound was developed by Abbott. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
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Sold under license from Abbott Laboratories

100

≥98% (HPLC)

solid

white

175.2-176.7 ℃

H₂O: 23 mg/mL

Abbott

2-8℃

5 mg in glass bottle

GHS05,GHS07,GHS09

Danger

H302 - H315 - H318 - H335 - H410

P261 - P273 - P280 - P301 + P312 - P302 + P352 - P305 + P351 + P338

Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Eye Dam. 1 - Skin Irrit. 2 - STOT SE 3

Respiratory system

11 - Combustible Solids

WGK 3

dust mask type N95 (US), Eyeshields, Gloves