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AA74-1
产品别名
1361532-00-4
AA74-1
[4-[1-Hydroxy-3-methyl-1-(2-methylpropyl)butyl]-2H-1,2,3-triazol-2-yl]-1-pyrrolidinylmethanone
[4-(4-Hydroxy-2,6-dimethylheptan-4-yl)-2H-1,2,3-triazol-2-yl](pyrrolidin-1-yl)methanone
结构式
基本信息
| Empirical Formula【经验(实验)分子式】 | C16H28N4O2 |
| Molecular weight | 308.42 |
| MDL number | MFCD23704789 |
| PubChem Substance ID【PubChem化学物质编号】 | 329825360 |
| NACRES | NA.77 |
| Biochem/physiol Actions【生化/生理作用】 | AA74-1 is an extremely potent and selective inhibitor of the serine hydrolase acyl-peptide hydrolase (APEH) with an IC50 of 5 nM in mouse T-cell proteomes. AA74-1 potently blocked the activity of its target serine hydrolase, APEH, in mice in vivo without significantly affecting other enzymes. The APEH inhibition caused accumulation of N-acetylated proteins and stimulated cellular proliferation in T cells. The APEH gene is deleted in some cancers, in which it has been proposed to serve as a potential tumor suppressor, and is involved in the degradation of oligomeric amyloid-beta which could make it a new target for therapy aimed at reducing neurodegeneration in Alzheimer′s disease. AA74-1 is the first selective tool for studying APEH activity. |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥98% (HPLC) |
| form【形式】 | film |
| color【颜色】 | colorless |
| solubility【溶解性】 | DMSO: >15 mg/mL |
| storage temp.【储存温度】 | 2-8℃ |
| SMILES string | CC(C)CC(O)(CC(C)C)c1cnn(n1)C(=O)N2CCCC2 |
| InChI | 1S/C16H28N4O2/c1-12(2)9-16(22,10-13(3)4)14-11-17-20(18-14)15(21)19-7-5-6-8-19/h11-13,22H,5-10H2,1-4H3 |
| InChI key | GXBVPGCIMCIASQ-UHFFFAOYSA-N |
| packaging【包装】 | 5, 25 mg in glass bottle |
安全信息
| Storage Class Code【储存分类代码】 | 13 - Non Combustible Solids |
| WGK | WGK 2 |
