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ABL127
产品价格查看更多规格...
| 产品编号 | 包装单位 | 单价(元) | 国内现货 | 国外库存 | 询价单 |
| 3336384 | 5 MG | 2020 | |||
| 3336384 | 25 MG | 5960 |
产品别名
1073529-41-5
ABL127
(3R)-Dimethyl 3-cyclopentyl-4-oxo-3-phenyl-1,2-diazetidine-1,2-dicarboxylate
(3R)-1,2-Dicarboxylic acid, 3-cyclopentyl-4-oxo-3-phenyl-1,2-diazetidine 1,2-dimethyl ester
CID24856225
结构式
基本信息
| Empirical Formula【经验(实验)分子式】 | C17H20N2O5 |
| Molecular weight | 332.35 |
| MDL number | MFCD28053514 |
| PubChem Substance ID【PubChem化学物质编号】 | 329825301 |
| NACRES | NA.77 |
| Biochem/physiol Actions【生化/生理作用】 | ABL127 is a potent and selective inhibitor of Protein phosphatase methylesterase-1 (PME-1 or PPME-1). IC50 values were 11.1 nM and 6.4 nM in MDA-MB-231 and HEK 293T cells with no activity detected against >50 other serine hydrolases. PME-1 regulates the methylesterification state of protein phosphatase 2A (PP2A) and is implicated in cancer and neurodegeneration. |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥98% (HPLC) |
| form【形式】 | film |
| color【颜色】 | colorless |
| solubility【溶解性】 | DMSO: ≥5 mg/mL |
| storage temp.【储存温度】 | 2-8℃ |
| SMILES string | O=C1[C@](C2=CC=CC=C2)(C3CCCC3)N(C(OC)=O)N1C(OC)=O |
| InChI | 1S/C17H20N2O5/c1-23-15(21)18-14(20)17(13-10-6-7-11-13,19(18)16(22)24-2)12-8-4-3-5-9-12/h3-5,8-9,13H,6-7,10-11H2,1-2H3/t17-/m0/s1 |
| InChI key | ZRHWCAFAIHTQKD-KRWDZBQOSA-N |
| packaging【包装】 | 5, 25 mg in glass bottle |
安全信息
| Storage Class Code【储存分类代码】 | 13 - Non Combustible Solids |
| WGK | WGK 3 |
