醋硝香豆素

C₁₉H₁₅NO₆

353.33

205-807-3

MFCD00137816

329825137

NA.77

Acenocoumarol was used to study the role of P-glycoprotein in transport of oral vitamin K in Caco-2 cells and as an LC/MS standard.
Acenocoumarol has been used as a standard for the determination of coumarins in cosmetics.

Acenocoumarol is effective against thromboembolic disorders.
Acenocoumarol is a warfarin analog, an anticoagulant that inhibits Vitamin K epoxide reductase. This results in depletion of the reduced form of vitamin K (vitamin KH2), limiting the gamma-carboxylation and subsequent activation of the vitamin K-dependent coagulation factors II, VII, IX, and X and anticoagulant proteins C and S, resulting in decreased prothrombin levels and the amount of thrombin generated.

This compound was developed by Novartis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

≥98% (HPLC)

powder

white to tan

DMSO, heptane and xylene: ≥17 mg/mL

Novartis

−20℃

CC(=O)CC(c1ccc(cc1)[N+]([O-])=O)C2=C(O)c3ccccc3OC2=O

1S/C19H15NO6/c1-11(21)10-15(12-6-8-13(9-7-12)20(24)25)17-18(22)14-4-2-3-5-16(14)26-19(17)23/h2-9,15,22H,10H2,1H3

VABCILAOYCMVPS-UHFFFAOYSA-N

human ... VKORC1(79001)

10, 50 mg in glass bottle

GHS07

Warning

H302 - H315 - H319 - H335

P261 - P264 - P270 - P301 + P312 - P302 + P352 - P305 + P351 + P338

Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Respiratory system

11 - Combustible Solids

WGK 3