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Acetylethylcholine mustard hydrochloride
| 产品编号： | 3337929 |
| 规格： | >97% (GC), powder |
| CAS NO： | 103994-00-9 |
| 包装规格： | 5 MG，25 MG |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品别名
103994-00-9
Acetylethylcholine mustard hydrochloride
Acetyl AF-64
结构式
基本信息
| Empirical Formula【经验(实验)分子式】 | C8H16ClNO2 · HCl |
| Molecular weight | 230.13 |
| MDL number | MFCD00055153 |
| PubChem Substance ID【PubChem化学物质编号】 | 329774756 |
| NACRES | NA.77 |
| Application【应用】 | Acetylethylcholine mustard hydrochloride has been used as a precursor in ethylcholine aziridinium (AF64A) preparation. It has also been used in the pharmacokinetic study to investigate its role in neuromuscular junction (NMJ) signal transmission and function. |
| Biochem/physiol Actions【生化/生理作用】 | Acetylethylcholine mustard is a precursor for ethylcholine mustard aziridinium ion (AF-64A); irreversible ligand for the high affinity choline transport system; specific presynaptic long action cholinotoxin; inhibitor of choline acetyl-transferase. Acetylethylcholine mustard hydrochloride can reduce the contraction frequency of the myotubes by inhibiting the synthesis of acetylethylcholine (Ach) with the half-maximal inhibitory concentration (IC50) of 1.22 mM. |
| Caution【注意】 | Extremely hygroscopic. |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | >97% (GC) |
| form【形式】 | powder |
| storage condition【储存条件】 | desiccated |
| color【颜色】 | white |
| mp | 78-81 ℃ |
| solubility【溶解性】 | H2O: >5 mg/mL ethanol: soluble methanol: soluble |
| storage temp.【储存温度】 | −20℃ |
| SMILES string | Cl[H].CCN(CCCl)CCOC(C)=O |
| InChI | 1S/C8H16ClNO2.ClH/c1-3-10(5-4-9)6-7-12-8(2)11;/h3-7H2,1-2H3;1H |
| InChI key | CHWPASAPXMNLKO-UHFFFAOYSA-N |
| packaging【包装】 | 5, 25 mg in glass bottle |
安全信息
| Pictograms【象形图】 | GHS06,GHS08 |
| Signal word【警示用语：】 | Danger |
| Hazard Statements | H300 + H310 + H330 - H315 - H319 - H335 - H370 |
| Precautionary Statements | P260 - P262 - P280 - P302 + P352 + P310 - P304 + P340 + P310 - P305 + P351 + P338 |
| Hazard Classifications【危险分类】 | Acute Tox. 2 Dermal - Acute Tox. 2 Inhalation - Acute Tox. 2 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 1 - STOT SE 3 |
| Target Organs【靶器官】 | Nervous system, Respiratory system |
| Storage Class Code【储存分类代码】 | 6.1A - Combustible, acute toxic Cat. 1 and 2 / very toxic hazardous materials |
| WGK | WGK 3 |
| Flash Point(F)【闪点(F)】 | 204.8 °F - closed cup |
| Flash Point(C)【闪点(C)】 | 96 ℃ - closed cup |
