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Adenosine 5′-[β-thio]diphosphate trilithium salt
产品别名
73536-95-5
Adenosine 5′-[β-thio]diphosphate trilithium salt
Adenosine-5′-0-(2-thiodiphosphate) trilithium salt
Ado-5′-PP[S]
ADP-β-S
结构式
基本信息
| Empirical Formula【经验(实验)分子式】 | C10H12Li3N5O9P2S |
| Molecular weight | 461.07 |
| MDL number | MFCD00077314 |
| eCl@ss | 32160414 |
| PubChem Substance ID【PubChem化学物质编号】 | 24891307 |
| NACRES | NA.77 |
| Application【应用】 | Adenosine 5′-[β-thio]diphosphate trilithium salt has been used to induce neuropathic pain in rats to study the effect of dorsal horn cannabinoid CB2 receptor activation on the expression of P2Y12 and P2Y13 (purinoceptors) receptors. Adenosine 5′-[β-thio]diphosphate is a substrate and inhibitor for AMP dependent enzyme systems. Adenosine 5′-[β-thio]diphosphate has been used to explore the myenteric control mechanisms of human esophageal motility and the effect of nitrergic and nonnitrergic neurotransmitters. |
| Biochem/physiol Actions【生化/生理作用】 | P2Y 受体激动剂。 |
| Features and Benefits【特点和优势】 | This compound is featured on the P2 Receptors: P2Y G-Protein Family page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here. |
| Other Notes【其他说明】 | Non-hydrolyzable ADP analog |
| Substrates【底物】 | Substrate and inhibitor for AMP dependent enzyme systems. |
产品性质
| Quality Level【质量水平】 | 200 |
| Assay【测定】 | ≥80% (HPLC) |
| form【形式】 | powder |
| storage temp.【储存温度】 | −20℃ |
| SMILES string | [Li+].[Li+].[Li+].Nc1ncnc2n(cnc12)[C@@H]3O[C@H](COP([O-])(=O)OP([O-])([O-])=S)[C@@H](O)[C@H]3O |
| InChI | 1S/C10H15N5O9P2S.3Li/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(23-10)1-22-25(18,19)24-26(20,21)27;;;/h2-4,6-7,10,16-17H,1H2,(H,18,19)(H2,11,12,13)(H2,20,21,27);;;/q;3*+1/p-3/t4-,6-,7-,10-;;;/m1.../s1 |
| InChI key | CPKFUAYUUSSFFZ-MSQVLRTGSA-K |
安全信息
| Pictograms【象形图】 | GHS07,GHS08 |
| Signal word【警示用语：】 | Warning |
| Hazard Statements | H302 - H371 |
| Precautionary Statements | P301 + P312 + P330 - P308 + P311 |
| Hazard Classifications【危险分类】 | Acute Tox. 4 Oral - STOT SE 2 |
| Target Organs【靶器官】 | Eyes |
| Storage Class Code【储存分类代码】 | 11 - Combustible Solids |
| WGK | WGK 3 |
| Personal Protective Equipment【个人防护装备】 | dust mask type N95 (US), Eyeshields, Faceshields, Gloves |
