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AEG 3482
产品别名
63735-71-7
AEG 3482
6-Phenyl-imidazo[2,1-b]-1,3,4-thiadiazole-2-sulfonamide
结构式
基本信息
| Empirical Formula【经验(实验)分子式】 | C10H8N4O2S2 |
| Molecular weight | 280.33 |
| MDL number | MFCD02064987 |
| PubChem Substance ID【PubChem化学物质编号】 | 329825272 |
| NACRES | NA.77 |
| Biochem/physiol Actions【生化/生理作用】 | AEG3284 is a compound that binds to heat shock protein 90 (HSP90), leading to heat shock factor 1 (HSF1) dependent expression of HSP70, an endogenous inhibitor of c-Jun N-terminal kinase (JNK) activity. Treatment of PC12 cells with AEF3284 blocks JNK dependent apoptosis. AEG 3482 is an imidazothiadiazole sulfonamide of 281 D with an anti-apoptotic property. |
| Features and Benefits【特点和优势】 | This compound is featured on the MAPKs page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here. |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥98% (HPLC) |
| form【形式】 | powder |
| color【颜色】 | faintly yellow to dark yellow |
| solubility【溶解性】 | DMSO: ≥15 mg/mL |
| storage temp.【储存温度】 | 2-8℃ |
| SMILES string | NS(=O)(=O)c1nn2cc(nc2s1)-c3ccccc3 |
| InChI | 1S/C10H8N4O2S2/c11-18(15,16)10-13-14-6-8(12-9(14)17-10)7-4-2-1-3-5-7/h1-6H,(H2,11,15,16) |
| InChI key | MQUYTXDAVCOCMX-UHFFFAOYSA-N |
| packaging【包装】 | 5, 25 mg in glass bottle |
安全信息
| Pictograms【象形图】 | GHS07 |
| Signal word【警示用语：】 | Warning |
| Hazard Statements | H302 |
| Hazard Classifications【危险分类】 | Acute Tox. 4 Oral |
| Storage Class Code【储存分类代码】 | 13 - Non Combustible Solids |
| WGK | WGK 3 |
