您的位置：首页 > 产品中心 > 102394-31-0， AF-DX 116
AF-DX 116
产品价格查看更多规格...
| 产品编号 | 包装单位 | 单价(元) | 国内现货 | 国外库存 | 询价单 |
| 3338664 | 5 MG | 1410 | |||
| 3338664 | 25 MG | 4160 |
产品别名
102394-31-0
AF-DX 116
Otenzepad
11-[[2-[(Diethylamino)methyl]-1-piperidinyl]acetyl]-5,1 1-dihydro-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one
结构式
基本信息
| Empirical Formula【经验(实验)分子式】 | C24H31N5O2 |
| Molecular weight | 421.54 |
| MDL number | MFCD00864743 |
| PubChem Substance ID【PubChem化学物质编号】 | 329824718 |
| NACRES | NA.77 |
| Application【应用】 | AF-DX 116 has been used as an M2 muscarinic acetylcholine receptor (M2AChR) selective antagonist to study the influence of M2AChR in the regulation of both basal and carbachol-stimulated long-term potentiation at the dentate gyrus (DG-LTP) and pro-nerve growth factor (proNGF) secretion in hippocampal cells of young diabetic rats. |
| Biochem/physiol Actions【生化/生理作用】 | AF-DX 116 raises blood pressure and heart rate in a rat model of hypotension induced by repeated cold stress. Thus, it may be used as a therapeutic for hypotension related to vagotonia type autonomic dysfunction. AF-DX 116 is a selective M2 muscarinic acetylcholine receptor antagonist. |
| Features and Benefits【特点和优势】 | This compound is featured on the Acetylcholine Receptors (Muscarinic) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here. |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥98% (HPLC) |
| form【形式】 | powder |
| drug control | regulated under CDSA - not available from sigma-aldrich Canada |
| color【颜色】 | white to beige |
| solubility【溶解性】 | DMSO: 5 mg/mL (clear solution; warmed) |
| storage temp.【储存温度】 | room temp |
| SMILES string | CCN(CC)CC1CCCCN1CC(=O)N2c3ccccc3C(=O)Nc4cccnc24 |
| InChI | 1S/C24H31N5O2/c1-3-27(4-2)16-18-10-7-8-15-28(18)17-22(30)29-21-13-6-5-11-19(21)24(31)26-20-12-9-14-25-23(20)29/h5-6,9,11-14,18H,3-4,7-8,10,15-17H2,1-2H3,(H,26,31) |
| InChI key | UBRKDAVQCKZSPO-UHFFFAOYSA-N |
| packaging【包装】 | 5, 25 mg in glass bottle |
安全信息
| Pictograms【象形图】 | GHS07 |
| Signal word【警示用语：】 | Warning |
| Hazard Statements | H302 |
| Hazard Classifications【危险分类】 | Acute Tox. 4 Oral |
| Storage Class Code【储存分类代码】 | 13 - Non Combustible Solids |
| WGK | WGK 3 |
