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AG-09/1
产品别名
356776-32-4
AG-09/1
2-[(6-methoxy-1H-benzimidazol-2-yl)thio]-N-(4-nitrophenyl)-acetamide
结构式
基本信息
| Empirical Formula【经验(实验)分子式】 | C16H14N4O4S |
| Molecular weight | 358.37 |
| MDL number | MFCD02321063 |
| PubChem Substance ID【PubChem化学物质编号】 | 329771051 |
| NACRES | NA.77 |
| Biochem/physiol Actions【生化/生理作用】 | AG-09/1 is a selective formyl peptide receptor 1 (FPR1) agonist; it activates chemotaxis in human neutrophils. Formyl peptide recetors (FPRs) are GPCRs mainly expressed in phagocytic leukocytes but with lower expression in many other cell types. Formyl peptides, act as Alarmins and are released from bacteria and damaged mitochondria, serving as chemoattractants for phagocyte recruitment to sites of inflammation, resulting in immune response. Because the endogenous ligands for FPRs are peptides and arachidonic acid metabolites, there are few small molecule tools for these receptors. A recent HTS of commercially available libraries yielded several FPR-1 selective agonists, of which AG-091 was the most potent. AG-091 induced intracellular calcium flux in FPR-1- but not FPR-2-expressing cells. It also caused chemotaxis and intracellular calcium flux in human leukocytes. AG-091 is a valuable tool for studying FPR1 function in immune and other disease states. |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥98% (HPLC) |
| form【形式】 | powder |
| color【颜色】 | yellow to brown |
| solubility【溶解性】 | DMSO: ≥30 mg/mL |
| storage temp.【储存温度】 | 2-8℃ |
| SMILES string | COc1ccc2[nH]c(SCC(=O)Nc3ccc(cc3)[N+]([O-])=O)nc2c1 |
| InChI | 1S/C16H14N4O4S/c1-24-12-6-7-13-14(8-12)19-16(18-13)25-9-15(21)17-10-2-4-11(5-3-10)20(22)23/h2-8H,9H2,1H3,(H,17,21)(H,18,19) |
| InChI key | LYQDSNOFTIZWAX-UHFFFAOYSA-N |
| packaging【包装】 | 5, 25 mg in glass bottle |
安全信息
| Pictograms【象形图】 | GHS05 |
| Signal word【警示用语：】 | Danger |
| Hazard Statements | H318 |
| Precautionary Statements | P280 - P305 + P351 + P338 |
| Hazard Classifications【危险分类】 | Eye Dam. 1 |
| Storage Class Code【储存分类代码】 | 11 - Combustible Solids |
| WGK | WGK 1 |
