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Anagrelide hydrochloride
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| 产品编号 | 包装单位 | 单价(元) | 国内现货 | 国外库存 | 询价单 |
| 3341954 | 10 MG | 1530 | |||
| 3341954 | 50 MG | 4490 |
产品别名
58579-51-4
Anagrelide hydrochloride
6,7-Dichloro-1,5-dihydro-imidazo[2,1-b]quinazolin-2(3H)-one hydrochloride
基本信息
| Empirical Formula【经验(实验)分子式】 | C10H7Cl2N3O · HCl |
| Molecular weight | 292.55 |
| NACRES | NA.77 |
| General description【一般描述】 | Anagrelide belongs to the imidazo[2,1-b]quinazolin-2-one series of compounds. Download the CofA, SDS and IFU specific to your product lot and format Fab fragments from polyclonal anti-fluorescein antibodies, conjugated to alkaline phosphatase. After immunization with fluorescein, the sheep IgG was purified by ion exchange chromatography and the specific IgG was isolated by immunosorption. The Fab fragments obtained by papain digestion were purified by gel filtration, conjugated with alkaline phosphatase, and stabilized in 50 mM triethanolamine buffer, 3 M NaCl, 1 mM MgCl2, 0.1 mM ZnCl2, 1% bovine serum albumin (w/v), pH 7.6. Clone: polyclonal Ig class: sheep IgG, Fab fragments |
| Biochem/physiol Actions【生化/生理作用】 | Anagrelide is a phosphodiesterase inhibitor with antiplatelet activity (IC50 = 36 nM for inhibition of phosphodiesterase-III). Anagrelide inhibits the maturation of megakaryocytes into platelets, reducing both megakaryocyte hyperproliferation and differentiation. As a drug, anagrelide is antithrombocythemic used for the treatment of overproduction of blood platelets. Anagrelide is a phosphodiesterase inhibitor with antiplatelet activity. In human and animals, anagrelide has an inhibitory effect on platelet aggregation. Small doses of anagrelide can generate thrombocytopenia. Anagrelide is not advised during pregnancy. It is effectively used in the treatment of essential thrombocytosis. |
| Features and Benefits【特点和优势】 | This compound is featured on the Phosphodiesterases page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here. This compound is a featured product for Cyclic Nucleotide research. Click here to discover more featured Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm. |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥98% (HPLC) |
| form【形式】 | powder |
| storage condition【储存条件】 | desiccated |
| color【颜色】 | white to beige |
| solubility【溶解性】 | DMSO: 1 mg/mL, clear (warmed) |
| storage temp.【储存温度】 | 2-8℃ |
| InChI | 1S/C10H7Cl2N3O.ClH/c11-6-1-2-7-5(9(6)12)3-15-4-8(16)14-10(15)13-7;/h1-2H,3-4H2,(H,13,14,16);1H |
| InChI key | TVWRQCIPWUCNMI-UHFFFAOYSA-N |
| packaging【包装】 | 10, 50 mg in glass bottle |
安全信息
| Pictograms【象形图】 | GHS08 |
| Signal word【警示用语：】 | Warning |
| Hazard Statements | H351 - H361d - H413 |
| Precautionary Statements | P202 - P273 - P280 - P308 + P313 - P405 - P501 |
| Hazard Classifications【危险分类】 | Aquatic Chronic 4 - Carc. 2 - Repr. 2 |
| Storage Class Code【储存分类代码】 | 11 - Combustible Solids |
| WGK | WGK 3 |
