Anti-α-MSH antibody produced in rabbit

MFCD03454727

NA.46

Pro-opiomelanocortin (POMC), a complex pro-peptide is expressed in hypothalamus, pituitary gland, skin and the immune system. This gene is located on human chromosome 2p23.3.

synthetic α-MSH peptide conjugated to bovine serum albumin.

Anti-α-MSH antibody produced in rabbit has been used in:

• immunohistochemistry
• radioimmunoassay/α-MSH immunoassay
• enzyme linked immunosorbent assay (ELISA)

α-MSH (melanocyte stimulating hormone) and melanocortin-4-receptor (MC4R) are key signaling components in the control of energy homeostasis and of the hypothalamic response to obesity. Mutations that reduce the functional activity of -MSH lead to obesity in mammals and mice lacking the MC4 receptor (MC4R-/-) are hyperphagic and very obese, indicating that -MSH signaling transduced by MC4-R limits food intake and body fat mass.
α-Melanocyte Stimulating Hormone (α-MSH) stimulates the production of melanin in melanocytes and induced pigmentation and skin darkening. It increases the activity of tyrosinase that induces melanogenesis. α-MSH has potent anti-inflammatory effects and is also a neuromodulator. Analogs of α-MSH may be used to study melanogenesis and neuromodulation.

0.01M 磷酸缓冲盐溶液，pH 7.4，含 15mM 叠氮化钠。

rabbit

200

unconjugated

IgG fraction of antiserum

primary antibodies

polyclonal

buffered aqueous solution

antigen 1664.9 kDa

human

ELISA: 1:4,000
microarray: suitable

P01189

dry ice

−20℃

human ... POMC(5443)

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