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Anti-ADAMTS-12 antibody produced in chicken
| 产品编号： | 3343327 |
| 规格： | affinity isolated antibody, buffered aqueous solution |
| 包装规格： | 50 μG |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
基本信息
| NACRES | NA.41 |
| General description【一般描述】 | A disintegrin and metalloproteinase with thrombospondin motifs 12 is an enzyme encoded by the ADAMTS12 gene in humans. It belongs to the family of metalloproteinases that helps in mediating a communication between specific cell types and plays a key role in the regulation of normal tissue development, remodeling and degradation. |
| Immunogen【免疫原】 | Immunogen Sequence: GI # 13569928, sequence 297-446 Recombinant A disintegrin-like and metalloprotease with thrombospondin type 1 motif, 12 |
| Application【应用】 | Anti-ADAMTS-12 antibody produced in chicken is suitbale for western blotting analysis at a dilution of 1:500, for tissue or cell staining at a dilution of 1:200. |
| Biochem/physiol Actions【生化/生理作用】 | ADAMTS12 is a degradative enzyme that interacts with the degradable fragments of cartilage oligomeric matrix protein, which is a prominent non-collagenous matrix component in articular cartilage. The protein exhibits a propeptide and metalloproteinase-like, disintegrin-like cysteine-rich domains. It may play a crutial role in pulmonary cells during fetal development or in tumor processes through its proteolytic activity or as a molecule potentially involved in regulation of cell adhesion. ADAMTS12 is found in cartilage, synovial fluid and serum of arthritic patients and may play an important role in the pathogenesis of arthritis. It may be a susceptibile gene for rheumatoid arthritis development. The genetic variations in ADAMTS12 is found to influence the risk of schizophrenia. |
| Physical form【外形】 | Solution in phosphate buffered saline containing 0.02% sodium azide. |
产品性质
| biological source【生物来源】 | chicken |
| conjugate【偶联物】 | unconjugated |
| antibody form【抗体形式】 | affinity isolated antibody |
| antibody product type | primary antibodies |
| clone【克隆】 | polyclonal |
| form【形式】 | buffered aqueous solution |
| species reactivity | mouse, human, rat |
| manufacturer/tradename | Genway 15-288-22831 |
| technique(s) | western blot: suitable |
| NCBI accession no.【NCBI登记号】 | NP_112217.1 |
| UniProt accession no.【UniProt登记号】 | P58397 |
| shipped in【运输】 | wet ice |
| storage temp.【储存温度】 | −20℃ |
| Gene Information | human ... ADAMTS12(81792) |
产品说明
| Disclaimer【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
安全信息
| Storage Class Code【储存分类代码】 | 12 - Non Combustible Liquids |
| WGK | WGK 1 |
| Personal Protective Equipment【个人防护装备】 | Eyeshields, Gloves, multi-purpose combination respirator cartridge (US) |
