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Anti-APOE (C-terminal) antibody produced in rabbit

产品编号:3345450
包装规格:100 μL
产品类别:进口试剂
品牌:Sigma-Aldrich
优惠价:立即咨询
产品价格
产品编号包装单位单价(元)国内现货国外库存询价单
3345450100 μL5730
产品别名

Anti-APOE (C-terminal) antibody produced in rabbit

LDLCQ5

LPG

AD2

基本信息
NACRES
NA.41
General description【一般描述】
Apolipoprotein E (ApoE) belongs to a group of proteins that bind reversibly with lipoproteins. Significant quantities of ApoE are produced in liver and brain and to some extent in almost every organ. ApoE is an important constituent of all plasma lipoproteins. ApoE exists in three major isoforms; E2, E3, and E4, which differ from one another by a single amino-acid substitution. Compared with E3 and E4, E2 exhibits the lowest receptor binding affinity. E2 allele carriers have significantly lower levels of total cholesterol, low-density lipoprotein cholesterol, and non-high-density lipoprotein cholesterol, as well as increased ApoE levels. The gene encoding this protein is localized on human chromosome 19q13.32.
Immunogen【免疫原】
Synthetic peptide corresponding to a region within amino acids 255 and 317 of Apolipoprotein E (Uniprot ID#P02649)
Application【应用】
Suggested starting dilutions are as follows: ICC/IF: 1:100-1:1000, IHC-P: 1:100-1:1000, IP: 1:100-1:500, WB: 1:500-1:10000. Not yet tested in other applications. Optimal working dilutions should be determined experimentally by the end user.
Biochem/physiol Actions【生化/生理作用】
In addition to facilitating solubilization of lipids, apolipoproteins help to maintain the structural integrity of lipoproteins, serve as ligands for lipoprotein receptors, and regulate the activity of enzymes involved in lipid metabolism. Apolipoprotein E (ApoE) plays an important role in lipid metabolism. It′s interaction with specific ApoE receptor enables uptake of chylomicron remnants by liver cells, which is an essential step during normal lipid metabolism. It also binds with the LDL receptor (Apo B/E). Defects in ApoE are a cause of hyperlipoproteinemia type III.
Features and Benefits【特点和优势】
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
Physical form【外形】
1XPBS, 20% Glycerol (pH7). 0.025% ProClin 300 was added as a preservative.
产品性质
biological source【生物来源】
rabbit
Quality Level【质量水平】
100
conjugate【偶联物】
unconjugated
antibody form【抗体形式】
purified immunoglobulin
antibody product type
primary antibodies
clone【克隆】
polyclonal
form【形式】
liquid
mol wt【分子量】
36 kDa
species reactivity
human
concentration【浓度】
1 mg/mL
technique(s)
immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable
immunoprecipitation (IP): suitable
western blot: 500-10000
UniProt accession no.【UniProt登记号】
P02649
shipped in【运输】
wet ice
storage temp.【储存温度】
−20℃
Gene Information
human ... APOE(348)
产品说明
Disclaimer【免责声明】
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
安全信息
Pictograms【象形图】
GHS07
Signal word【警示用语:】
Warning
Hazard Statements
H317 - H412
Precautionary Statements
P261 - P272 - P273 - P280 - P302 + P352 - P333 + P313
Hazard Classifications【危险分类】
Aquatic Chronic 3 - Skin Sens. 1
Storage Class Code【储存分类代码】
12 - Non Combustible Liquids
WGK
WGK 2
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