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Anti-BAD (Ab-136) antibody produced in rabbit
产品别名
Anti-BAD (Ab-136) antibody produced in rabbit
Anti-BCL2L8 antibody produced in rabbit
Anti-BBC2 antibody produced in rabbit
Anti-BCL2-associated agonist of cell death antibody produced in rabbit
基本信息
| MDL number | MFCD02097156 |
| NACRES | NA.41 |
| General description【一般描述】 | BAD (BCL2 associated agonist of cell death) is a proapoptotic protein. It is a 184 kDa protein made of 168 amino acids. It belongs to the Bcl2 family of proteins. The gene encoding it is localized on human chromosome 11q13. |
| Immunogen【免疫原】 | Peptide sequence around aa. 134-138 (S-R-S-A-P), according to the protein BAD. |
| Biochem/physiol Actions【生化/生理作用】 | Phosphorylated BAD (BCL2 associated agonist of cell death) has the ability to interact with 14-3-3 scaffold proteins in the cytoplasm. Dephosphorylated BAD is active and it moves to the outer membrane of mitochondria and make heterodimers with BCL-XL to prevent BCL-XL antiapoptotic activities. |
| Features and Benefits【特点和优势】 | Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more. |
| Physical form【外形】 | Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol |
产品性质
| biological source【生物来源】 | rabbit |
| conjugate【偶联物】 | unconjugated |
| antibody form【抗体形式】 | affinity isolated antibody |
| antibody product type | primary antibodies |
| clone【克隆】 | polyclonal |
| form【形式】 | buffered aqueous solution |
| mol wt【分子量】 | ~23 kDa |
| species reactivity | rat, human, mouse |
| concentration【浓度】 | 1 mg/mL |
| technique(s) | immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:50-1:100 western blot: 1:500-1:1000 |
| isotype【同位素/亚型】 | IgG |
| immunogen sequence【免疫原序列】 | (S-R-S-A-P) |
| NCBI accession no.【NCBI登记号】 | NP_004313.1 |
| UniProt accession no.【UniProt登记号】 | Q92934 |
| shipped in【运输】 | wet ice |
| storage temp.【储存温度】 | −20℃ |
| Gene Information | human ... BAD(572) |
产品说明
| Target description【目标描述】 | The protein encoded by BAD gene is a member of the BCL-2 family. BCL-2 family members are known to be regulators of programmed cell death. This protein positively regulates cell apoptosis by forming heterodimers with BCL-xL and BCL-2, and reversing their death repressor activity. Proapoptotic activity of this protein is regulated through its phosphorylation. Protein kinases AKT and MAP kinase, as well as protein phosphatase calcineurin were found to be involved in the regulation of this protein. Alternative splicing of this gene results in two transcript variants which encode the same isoform. |
安全信息
| Storage Class Code【储存分类代码】 | 10 - Combustible liquids |
| WGK | WGK 1 |
