Anti-Bad antibody produced in rabbit

MFCD03791437

NA.41

Bad (Bcl-2-antagonist of cell death), initially identified by its interaction with Bcl-2 and Bcl-XL, is a distant Bcl-2 family member. Bad bears only the most universally conserved amino acids within BH1 and BH2 domains, and lacks the typical hydrophobic C-terminal signal anchor.

synthetic peptide corresponding to amino acids 1-21 of human Bad conjugated to KLH.

Anti-Bad antibody produced in rabbit is suitable for western blotting at a concentration of 1μg/mL

The protein encoded by this gene forms heterodimers with BCL-xL and BCL-2 and replaces Bax, which in turn inverts the death repressor activity of Bcl-xL and positively regulates cell apoptosis.Bad is phosphorylated on two serine residues embedded in canonical 14-3-3 binding sites in response to IL-3, a survival factor. Phosphorylated Bad does not bind Bcl-XL and is sequestered in the cytosol bound to 14-3-3, a specific phosphoserine-binding protein. The growth factors that promote cell survival activate the threonine kinase Akt, which phosphorylates Bad causing suppression of apoptosis.

lyophilized from a 0.2 μm filtered solution of phosphate buffered saline (PBS) and 5% trehalose

rabbit

100

unconjugated

affinity isolated antibody

primary antibodies

polyclonal

lyophilized powder

mouse, human

western blot: 1 μg/mL

Q92934

−20℃

human ... BAD(572)
mouse ... Bad(12015)

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13 - Non Combustible Solids

WGK 3

Eyeshields, Gloves, type N95 (US)