Anti-Bax antibody produced in rabbit

MFCD00282585

NA.46

Bax is a 21kD integral organelle membrane protein that belongs to the Bcl-2 family and is expressed mainly in the mitochondria. It exist in three cytosolic forms Bax β (24 kDa), Bax γ (5 kDa) and Bax δ (16 kDa) generated by alternative splicing.

synthetic peptide GGPTSSEQIMKTGALLLQGF-K corres- ponding to the N-terminal region of Bax of human origin (Bax α, amino acids 11-30 with C-terminally added lysine), conjugated to KLH as immunogen. This sequence is identical in human Bax β and highly conserved in rat and mouse Bax α (single amino acid substitution) and human Bax.

Anti-BMPR2 (836-850) antibody produced in rabbit is suitable for western blotting at a concentration of 1:500-1:2,000.

BAX is a proapoptotic protein that forms homodimer to accelerate apoptotic death whereas its heterodimerization with Bcl-2 or Bcl-xL can block apoptosis^. BAX binds to the mitochondrial permeability transition pore complex (PTPC), and when expressed in cells, it induces mitochondrial dysfunction and the release of cytochrome C, leading to activation of caspases and triggers apoptosis. Loss-of-function mutation in the BAX gene results in Hematopoietic malignancies.

0.01M 磷酸缓冲盐溶液，pH 7.4，含 15mM 叠氮化钠。

rabbit

200

unconjugated

IgG fraction of antiserum

primary antibodies

polyclonal

buffered aqueous solution

antigen 23 kDa

human, mouse, rat

microarray: suitable
western blot: 1:2,000 using whole cell extract of MCF7 human breast adenocarcinoma cell line

Q07812

dry ice

−20℃

human ... BAX(581)
mouse ... Bax(12028)
rat ... Bax(24887)

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12 - Non Combustible Liquids

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