Anti-BMI1 antibody produced in rabbit

NA.41

The human proto-oncogene BMI1 (also known as Polycomb complex protein BMI-1, Polycomb group RING finger protein 4, and RING finger protein 51) is a member of the mammalian Polycomb group (Pc-G) genes.

Anti-BMI1 antibody produced in rabbit may be used in several immunochemical techniques including immunoblotting (~37 kDa) and immunofluorescence.

BMI1 (Proto-Oncogene, Polycomb Ring Finger) plays an important role as epigenetic gene silencers during development. Elevated expression of BMI1 is associated with many cancers such as mantle cell lymphoma, B-cell non-Hodgkin′s lymphoma, myeloid leukemia, non-small cell lung cancer, colorectal cancer, breast cancer and prostate cancer. BMI1 has been shown to be also required for self-renewal of hematopoietic stem cells and neuronal stem cells. BMI1 knockout in mice results in defects in hematopoiesis, skeletal patterning and neurological functions.

Solution in 0.01 M phos­phate buffered saline, pH 7.4, containing 15 mM sodium azide.

rabbit

unconjugated

affinity isolated antibody

primary antibodies

polyclonal

buffered aqueous solution

antigen ~37 kDa

human

antibody small pack of 25 μL

~1.0 mg/mL

indirect immunofluorescence: 1-2 μg/mL using paraformaldehyde fixed HEK-293T cells over expressing human BMI1
western blot: 1-2 μg/mL using lysate of HEK-293T cells over expressing human BMI1

P35226

dry ice

−20℃

human ... BMI1(648)
mouse ... Bmi1(12151)
rat ... Bmi1(307151)

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12 - Non Combustible Liquids