Anti-c-Jun N-Terminal Kinase antibody produced in rabbit

MFCD00676444

NA.44

JNK (c-Jun N terminal protein kinase, also known as stress activated protein kinase, SAPK1) is a protein that belongs to serine/threonine-protein kinase family. It has a critical role in inhibiting WOX1 (WW domain-containing oxidoreductase) mediated apoptosis. It also mediates starvation-induced BCL2 phosphorylation and activates autophagy. Anti-c-Jun N-terminal kinase antibody can be used in microarray. Rabbit anti-c-Jun N-terminal kinase antibody reacts specifically with JNK1 (46 kD) and JNK2 (55 kD) of cell culture lysates and rat brain tissue extracts. The product has also shown weak cross reactivity for JNK2β (50 kD) isoform in mouse NIH-3T3 fibroblast cell lysate.
Anti-c-Jun N-Terminal Kinase (JNK1, JNK2) is developed in rabbit using a synthetic peptide, corresponding to amino acids of human c-Jun N-terminal kinase 1 (JNK1), coupled to KLH as the immunogen.

Synthetic peptide corresponding to amino acids 339-354 of human JNK1 (c-Jun N-terminal kinase 1), conjugated to KLH. The sequence is highly conserved in JNK1, JNK2 α, β, γ (p54 SAPK α, β, γ) and identical in human, rat, and mouse JNK1.

Anti-c-Jun N-Terminal Kinase antibody produced in rabbit has been used in western blotting.

Mitogen-activated protein kinases (MAPKs) are serine/threonine kinases which play a central role in mitogenic signaling. The MAPKs function to transduce extracellular signals to intracellular targets, including transcription factors controlling the expression of genes essential to many cellular processes including proliferation, development and differentiation. JNK1 is essential for tumor necrosis factor alpha (TNF-α)-induced c-Jun kinase activation, c-Jun expression, and apoptosis. JNK1 and JNK2 participates in the survival of neuronal cells.

rabbit

200

unconjugated

whole antiserum

primary antibodies

polyclonal

antigen, JNK1 46 kDa
antigen, JNK2 55 kDa

15 mM sodium azide

mouse, human, rat

microarray: suitable
western blot: 1:16,000 using rat brain extract and mouse NIH-3T3 fibroblast extract, respectively
western blot: 1:2,000 using mouse NIH 3T3 fibroblast cell lysate

P45983

dry ice

−20℃

human ... MAPK8(5599)
mouse ... Mapk8(26419)
rat ... Mapk8(116554)

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