Anti-CACNB4 antibody produced in rabbit

NA.41

CACNB4 codes for a beta subunit of the voltage-dependant calcium channel proteins. CACNB4 mutation has been linked to altered functions of Ca_v2.1 and other functional defects in juvenile myoclonic epilepsy.
Rabbit Anti-CACNB4 antibody recognizes chicken, canine, zebrafish, pig, rabbit, human, mouse, and rat CACNB4.

Synthetic peptide directed towards the C terminal region of human CACNB4

Rabbit Anti-CACNB4 antibody is suitable for western blot applications at 0.25 μg/ml.

CACNB4 is a member of the beta subunit family, a protein in the voltage-dependent calcium channel complex. CACNB4 plays an important role in calcium channel function by modulating G protein inhibition, increasing peak calcium current, controlling the alpha-1 subunit membrane targeting and shifting the voltage dependence of activation and inactivation. This gene encodes a member of the beta subunit family, a protein in the voltage-dependent calcium channel complex. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization and consist of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. Various versions of each of these subunits exist, either expressed from similar genes or the result of alternative splicing. The protein described in this record plays an important role in calcium channel function by modulating G protein inhibition, increasing peak calcium current, controlling the alpha-1 subunit membrane targeting and shifting the voltage dependence of activation and inactivation. Certain mutations in this gene have been associated with idiopathic generalized epilepsy (IGE) and juvenile myoclonic epilepsy (JME). Alternate transcriptional splice variants of this gene, encoding different isoforms, have been characterized.

Synthetic peptide located within the following region: LEAYWRATHTTSSTPMTPLLGRNLGSTALSPYPTAISGLQSQRMRHSNHS

Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

rabbit

100

unconjugated

affinity isolated antibody

primary antibodies

polyclonal

buffered aqueous solution

55 kDa

dog, rabbit, guinea pig, mouse, human, horse, rat, bovine

0.5 mg - 1 mg/mL

western blot: suitable

NP_000717

O00305-2

wet ice

−20℃

human ... CACNB4(785)

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12 - Non Combustible Liquids

WGK 2