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Anti-CARM1 (Ab-228) antibody produced in rabbit

产品编号:3350908
规格:affinity isolated antibody
包装规格:100 μG
产品类别:进口试剂
品牌:Sigma-Aldrich
优惠价:立即咨询
产品价格
产品编号包装单位单价(元)国内现货国外库存询价单
3350908100 μG4610
产品别名

Anti-CARM1 (Ab-228) antibody produced in rabbit

Anti-coactivator-associated arginine methyltransferase 1

Anti-PRMT4

基本信息
NACRES
NA.41
General description【一般描述】
The antibody detects endogenous levels of total CARM1 protein.
Immunogen【免疫原】
Peptide sequence around aa. 226-230 (V-K-S-N-N), according to the protein NP_954592.1
Features and Benefits【特点和优势】
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
Physical form【外形】
Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol
产品性质
biological source【生物来源】
rabbit
conjugate【偶联物】
unconjugated
antibody form【抗体形式】
affinity isolated antibody
antibody product type
primary antibodies
clone【克隆】
polyclonal
form【形式】
buffered aqueous solution
mol wt【分子量】
~63 kDa
species reactivity
rat, human, mouse
concentration【浓度】
1 mg/mL
technique(s)
indirect immunofluorescence: 1:100-1:200
western blot: 1:500-1:1000
isotype【同位素/亚型】
IgG
immunogen sequence【免疫原序列】
(V-K-S-N-N)
NCBI accession no.【NCBI登记号】
NM_199141.1
UniProt accession no.【UniProt登记号】
Q86X55
shipped in【运输】
wet ice
storage temp.【储存温度】
−20℃
Gene Information
human ... CARM1(10498)
产品说明
Target description【目标描述】
Methylates (mono- and asymmetric dimethylation) the guanidino nitrogens of arginyl residues in several proteins involved in DNA packaging, transcription regulation, and mRNA stability. Recruited to promoters upon gene activation together with histone acetyltransferases from EP300/P300 and p160 families, methylates histone H3 at ′Arg-17′ and activates transcription via chromatin remodeling. During nuclear hormone receptor activation and TCF7L2/TCF4 activation, acts synergically with EP300/P300 and either one of the p160 histone acetyltransferases NCOA1/SRC1, NCOA2/GRIP1 and NCOA3/ACTR or CTNNB1/beta-catenin to activate transcription. During myogenic transcriptional activation, acts together with NCOA3/ACTR as a coactivator for MEF2C. During monocyte inflammatory stimulation, acts together with EP300/P300 as a coactivator for NF-kappa-B. Also seems to be involved in p53/TP53 transcriptional activation. Methylates EP300/P300, both at ′Arg-2142′, which may loosen its interaction with NCOA2/GRIP1, and at ′Arg-580′ and ′Arg-604′ in the KIX domain, which impairs its interaction with CREB and inhibits CREB-dependent transcriptional activation. Also methylates arginine residues in RNA-binding proteins PABPC1, ELAVL1 and ELAV4, which may affect their mRNA-stabilizing properties and the half-life of their target mRNAs.
Disclaimer【免责声明】
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
安全信息
Storage Class Code【储存分类代码】
10 - Combustible liquids
WGK
WGK 1
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