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Anti-CASP-1 (Cleaved-Asp210) antibody produced in rabbit
产品别名
Anti-CASP-1 (Cleaved-Asp210) antibody produced in rabbit
ICE
IL-1BC
IL-1 β converting enzyme
IL-1 β
caspase-1
基本信息
| NACRES | NA.41 |
| General description【一般描述】 | Caspase-1 is also known as interleukin-1β converting enzyme (ICE). It is located on human chromosome 11q22.2. It has 10 exons, an N terminal CARD (caspase activation and recruitment domain), a large P20 subunit and a small P10 subunit. CASP-1 is present in leukocytes, monocytes and epithelial cells. Anti-CASP-1 (Cleaved-Asp210) Antibody detects endogenous levels of fragment of activated CASP-1 (Cleaved-Asp210) protein. |
| Immunogen【免疫原】 | The antiserum was produced against synthesized peptide derived from human IL-1 beta. Immunogen Range: 161-210 |
| Biochem/physiol Actions【生化/生理作用】 | Caspase-1 can transform pro-inflammatory cytokines, interleukin-1β (IL-1β) and interleukin-18 (IL-18) into their active forms. It participates in pyroptosis. It is overexpressed in the aorta of coronary atherosclerosis patients. CASP-1 helps in host cell survival by inducing membrane biogenesis to restore the impairment caused by pore-forming toxins. |
| Features and Benefits【特点和优势】 | Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more. |
| Physical form【外形】 | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
产品性质
| biological source【生物来源】 | rabbit |
| conjugate【偶联物】 | unconjugated |
| antibody form【抗体形式】 | affinity isolated antibody |
| antibody product type | primary antibodies |
| clone【克隆】 | polyclonal |
| form【形式】 | buffered aqueous solution |
| mol wt【分子量】 | antigen 25 kDa antigen 45 kDa |
| species reactivity | human |
| concentration【浓度】 | ~1 mg/mL |
| technique(s) | ELISA: 1:10000 immunohistochemistry: 1:50-1:100 western blot: 1:500-1:1000 |
| NCBI accession no.【NCBI登记号】 | P29466 |
| UniProt accession no.【UniProt登记号】 | P29466 |
| shipped in【运输】 | wet ice |
| storage temp.【储存温度】 | −20℃ |
| Gene Information | human ... CASP1(834) |
产品说明
| Disclaimer【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
安全信息
| Storage Class Code【储存分类代码】 | 12 - Non Combustible Liquids |
| WGK | nwg |
