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Anti-Caspase-1 (ab2) antibody produced in rabbit
| 产品编号： | 3351011 |
| 规格： | affinity isolated antibody, buffered aqueous solution |
| 包装规格： | 100 μG |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品别名
Anti-Caspase-1 (ab2) antibody produced in rabbit
Anti-ICE
Anti-Caspase 1, apoptosis-related cysteine peptidase (Interleukin 1, beta, convertase)
Anti-IL-1β converting enzyme
基本信息
| NACRES | NA.41 |
| General description【一般描述】 | Caspase-1 is also known as interleukin-1βconverting enzyme (ICE). It is located on chromosome 11q22.2. It has 10 exons, an N terminal CARD (caspase activation and recruitment domain), a large P20 subunit and a small P10 subunit. It is present in leukocytes, monocytes and epithelial cells. |
| Immunogen【免疫原】 | a 15 amino acid peptide from near the middle of human Caspase-1. |
| Biochem/physiol Actions【生化/生理作用】 | Caspase-1 can transform the pro-inflammatory cytokines, interleukin-1β (IL-1β) and IL-18 into their active forms. It participates in pyroptosis. It is overexpressed in the aorta of coronary atherosclerosis patients.It helps in host cell survival by inducing membrane biogenesis to restore the impairment caused by pore-forming toxins. |
| Linkage【联系】 | The action of this antibody can be blocked using blocking peptide SBP3463. |
| Physical form【外形】 | Solution in phosphate buffered saline containing 0.02% sodium azide |
产品性质
| biological source【生物来源】 | rabbit |
| conjugate【偶联物】 | unconjugated |
| antibody form【抗体形式】 | affinity isolated antibody |
| antibody product type | primary antibodies |
| clone【克隆】 | polyclonal |
| form【形式】 | buffered aqueous solution |
| species reactivity | human |
| technique(s) | immunofluorescence: suitable immunohistochemistry: suitable indirect ELISA: suitable western blot: suitable |
| UniProt accession no.【UniProt登记号】 | P29466 |
| shipped in【运输】 | dry ice |
| storage temp.【储存温度】 | −20℃ |
| Gene Information | human ... CASP1(834) |
安全信息
| Storage Class Code【储存分类代码】 | 12 - Non Combustible Liquids |
| WGK | WGK 2 |
