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Anti-CCRK (381-395) antibody produced in rabbit
| 产品编号： | 3351872 |
| 规格： | IgG fraction of antiserum, buffered aqueous solution |
| 包装规格： | 200 μL |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品别名
Anti-CCRK (381-395) antibody produced in rabbit
Anti-p42
Anti-CDCH
Anti-Cell cycle related kinase isoform 2 (Homo sapiens)
基本信息
| NACRES | NA.41 |
| Immunogen【免疫原】 | synthetic peptide corresponding to amino acids 381-395 of human CCRK. |
| Application【应用】 | Yale Center for High Throughput Cell Biology IF-tested antibodies. Each antibody is tested by immunofluorescence against HUVEC cells using the Yale HTCB IF protocol. To learn more about us and Yale Center for High Throughput Cell Biology partnership, visit sigma.com/htcb-if. Anti-CCRK (381-395) antibody produced in rabbit is suitable for western blotting at a dilution of 1:500-1:2,000. |
| Biochem/physiol Actions【生化/生理作用】 | Cell cycle-related kinase (CCRK) is a protein kinase that is homologous to Cdk7. It is a candidate for oncogene in human glioblastoma tumorigenesis. CCRK is also involved in colorectal cancer carcinogenesis and G1/S cell cycle transition by regulating Cdk2, cyclin E and Rb. CCRK plays an important role in the control of cell proliferation via the regulation of cyclin D1 expression, and the overexpression of CCRK. It also acts as an independent molecular marker for shortened survival time of patients with ovarian carcinoma. CCRK along with its substrate ICK (intestinal cell kinase) inhibits ciliogenesis and glioblastoma cell proliferation. Depletion of CCRK leads to accumulation of ICK at ciliary tips, altered ciliary transport and leads to inhibition of cell cycle re-entry in NIH3T3 fibroblasts. |
| Physical form【外形】 | 0.01M 磷酸缓冲盐溶液，pH 7.4，含 15mM 叠氮化钠。 |
产品性质
| biological source【生物来源】 | rabbit |
| Quality Level【质量水平】 | 200 |
| conjugate【偶联物】 | unconjugated |
| antibody form【抗体形式】 | IgG fraction of antiserum |
| antibody product type | primary antibodies |
| clone【克隆】 | polyclonal |
| form【形式】 | buffered aqueous solution |
| mol wt【分子量】 | antigen ~36 kDa |
| species reactivity | human |
| technique(s) | western blot: 1:500-1:2,000 |
| shipped in【运输】 | dry ice |
| storage temp.【储存温度】 | −20℃ |
| Gene Information | human ... CCRK(23552) |
安全信息
| Storage Class Code【储存分类代码】 | 12 - Non Combustible Liquids |
| WGK | WGK 2 |
| Personal Protective Equipment【个人防护装备】 | Eyeshields, Gloves, multi-purpose combination respirator cartridge (US) |
