Anti-CD19 antibody, Rabbit monoclonal

NA.41

CD19 is expressed in B lymphocytes and B-cell lymphoma. It may also be present on some early myeloid progenitors, particularly those of the monoblastic type. It appears to be expressed on myeloid leukemia cells, particularly those of monocytic lineage. Leukemia phenotype studies have demonstrated that the earliest and broadest B cell restricted antigen is the CD19 antigen. CD19 is negative in T lymphocytes, plasma cells, and their tumors.
CD19 (cluster of differentiation 19) is a 95 kDa protein localized on the surface of nearly all B lymphocytes and is considered to be the specific surface marker for B cells. This protein belongs to the immunoglobulin (Ig) superfamily with a cytoplasmic region of ∼240 amino acids and is involved in the regulation of B cell function. The gene encoding CD19 is localized on human chromosome 16p11.2.

Synthetic peptide corresponding to C-terminus of human CD19.

CD19 (cluster of differentiation 19) expression is restricted to normal and malignant B-lineage cells. Therefore, it is considered to be a striking target for immunotherapies aimed at B-cell malignancies. CD19 helps B lymphocytes to initiate primary immune response even at low concentrations of antigen. The encoded protein plays a crucial role in initiating intrinsic B cell signaling thresholds by regulating both B cell receptor (BCR)-dependent and independent signaling. It also functions as a biomarker for B-cell development.

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0.1 ml rabbit monoclonal antibody purified by protein A/G in PBS/1% BSA buffer pH 7.6 with less than 0.1% sodium azide.

rabbit

100

expressed in proprietary host

unconjugated

affinity isolated antibody

primary antibodies

SP110, monoclonal

human (tested)

flow cytometry: 1:100
immunohistochemistry: 1:200

IgG

P15391

wet ice

2-8℃

human ... CD19(930)

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12 - Non Combustible Liquids

WGK 2