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Anti-COIL antibody produced in rabbit
产品别名
Anti-COIL antibody produced in rabbit
Anti-coilin
Anti-CLN80
Anti-p80-coilin
基本信息
| NACRES | NA.41 |
| General description【一般描述】 | Coilin is a protein encoded by the COIL gene in humans. COIL (Coilin) gene encodes a nuclear phosphoprotein localized on to chromosome 17q22-23, which is an integral component of Cajal bodies (also called coiled bodies) and impacts small nuclear ribonucleoprotein (snRNP) biogenesis. |
| Immunogen【免疫原】 | Synthetic peptide directed towards the C terminal region of human COIL |
| Application【应用】 | Anti-COIL antibody produced in rabbit is suitable for western blotting at a concentration of 1μg/mL. |
| Biochem/physiol Actions【生化/生理作用】 | Coilin acts as glue to connect the CB to the nucleolus. It is considered to be the CB marker protein and is essential for proper CB formation and composition in mammalian cells. Coilin levels influences the proliferation rate and cell cycle distribution of cells exposed to etoposide. It facilitates the inhibition of RNA polymerase I during cisplatin-induced DNA damage. Coilin protein is also involved in the processing of human telomerase RNA. |
| Sequence【序列】 | Synthetic peptide located within the following region: DYSLLPLLAAAPQVGEKIAFKLLELTSSYSPDVSDYKEGRILSHNPETQQ |
| Physical form【外形】 | Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
产品性质
| biological source【生物来源】 | rabbit |
| Quality Level【质量水平】 | 100 |
| conjugate【偶联物】 | unconjugated |
| antibody form【抗体形式】 | affinity isolated antibody |
| antibody product type | primary antibodies |
| clone【克隆】 | polyclonal |
| form【形式】 | buffered aqueous solution |
| mol wt【分子量】 | 63 kDa |
| species reactivity | human |
| concentration【浓度】 | 0.5 mg - 1 mg/mL |
| technique(s) | western blot: suitable |
| NCBI accession no.【NCBI登记号】 | NP_004636 |
| UniProt accession no.【UniProt登记号】 | P38432 |
| shipped in【运输】 | wet ice |
| storage temp.【储存温度】 | −20℃ |
| Gene Information | human ... COIL(8161) |
产品说明
| Disclaimer【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
安全信息
| Storage Class Code【储存分类代码】 | 12 - Non Combustible Liquids |
| WGK | WGK 3 |
