Anti-CPNE1 antibody produced in rabbit

NA.41

Copines are a novel class of C2 domain-containing (the Ca2⁺-binding domain of PKC-gamma) phospholipid-binding proteins involved in membrane trafficking processes. Copine I is expressed in all major adult organs, especially spleen. Copine-1 participates in the formation of signaling complexes on membranes. Copine-I regulates the half-life of NF-kappaB transcriptional responses through a novel mechanism that involves endoproteolysis of the p65 protein.

Anti-CPNE1 polyclonal antibody reacts with canine, bovine, rabbit, human, mouse, rat, chicken, pig copine 1 proteins.

Synthetic peptide directed towards the N terminal region of human CPNE1

Anti-CPNE1 polyclonal antibody is used to tag Copine I proteins for detection and quantitation by Western blotting and in cells and tissues by immunohistochemical (IHC) techniques. It is used as a probe to study the role of copine I in membrane trafficking and signaling processes.

Calcium-dependent membrane-binding proteins may regulate molecular events at the interface of the cell membrane and cytoplasm. CPNE1 is a calcium-dependent protein that also contains two N-terminal type II C2 domains and an integrin A domain-like sequence in the C-terminus. However, the protein does not contain a predicted signal sequence or transmembrane domains. This protein has a broad tissue distribution and it may function in membrane trafficking.Calcium-dependent membrane-binding proteins may regulate molecular events at the interface of the cell membrane and cytoplasm. This gene encodes a calcium-dependent protein that also contains two N-terminal type II C2 domains and an integrin A domain-like sequence in the C-terminus. However, the encoded protein does not contain a predicted signal sequence or transmembrane domains. This protein has a broad tissue distribution and it may function in membrane trafficking. This gene and the gene for RNA binding motif protein 12 overlap at map location 20q11.21. Sequence analysis identified multiple alternatively spliced variants in the 5′ UTR. All variants encode the same protein.

Synthetic peptide located within the following region: TVQKLRFGIYDIDNKTPELRDDDFLGGAECSLGQIVSSQVLTLPLMLKPG

Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

rabbit

100

unconjugated

IgG fraction of antiserum

primary antibodies

polyclonal

buffered aqueous solution

59 kDa

human

0.5 mg - 1 mg/mL

immunohistochemistry: suitable
western blot: suitable

NP_003906

Q99829

wet ice

−20℃

human ... CPNE1(8904)

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WGK 3