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Anti-CX3CL1 antibody produced in rabbit
| 产品编号： | 3355956 |
| 规格： | affinity isolated antibody, buffered aqueous solution |
| 包装规格： | 100 μG |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品别名
Anti-CX3CL1 antibody produced in rabbit
Anti-chemokine (C-X3-C motif) ligand 1
Anti-CX3C
基本信息
| MDL number | MFCD01864668 |
| NACRES | NA.41 |
| General description【一般描述】 | Chemokine (C-X3-C motif) ligand 1 (CX3CL1) or fractalkine is a membrane protein and part of the CXC3 family. Its chemokine domain (CKD) anchors it to the cell membrane through its mucin-like stalk. The protein acts as a ligand for the G-protein coupled receptor CX3CR1. Fractalkine is expressed on epithelial, endothelial and smooth muscle cells and in neurons. The gene encoding it is localized on human chromosome 16q21. |
| Immunogen【免疫原】 | a peptide corresponding to 18 amino acids near the amino-terminus of human CX3CL1. |
| Biochem/physiol Actions【生化/生理作用】 | CX3CL1 (chemokine (C-X3-C motif) ligand 1) or fractalkine is involved in various disorders such as atherosclerosis, multiple sclerosis, neuropathic pain and rheumatic disorders. It facilitates the proliferation and survival of primary human vascular smooth muscle cells in an epidermal growth factor receptor (EGR)–dependent manner. The protein plays an essential role in cell survival and promotes the survival of cells such as monocytes, T-cells and microglia. In humans, it may be involved in atherogenesis. |
| Linkage【联系】 | The action of this antibody can be blocked using blocking peptide SBP2099. |
| Physical form【外形】 | Solution in phosphate buffered saline containing 0.02% sodium azide |
产品性质
| biological source【生物来源】 | rabbit |
| Quality Level【质量水平】 | 100 |
| conjugate【偶联物】 | unconjugated |
| antibody form【抗体形式】 | affinity isolated antibody |
| antibody product type | primary antibodies |
| clone【克隆】 | polyclonal |
| form【形式】 | buffered aqueous solution |
| species reactivity | human, mouse |
| technique(s) | immunoprecipitation (IP): suitable indirect ELISA: suitable western blot: suitable |
| UniProt accession no.【UniProt登记号】 | P78423 |
| shipped in【运输】 | dry ice |
| storage temp.【储存温度】 | −20℃ |
| Gene Information | human ... CX3CL1(6376) |
产品说明
| Disclaimer【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
安全信息
| Storage Class Code【储存分类代码】 | 12 - Non Combustible Liquids |
| WGK | WGK 2 |
