Anti-DMAP1 (AB2) antibody produced in rabbit

NA.41

DMAP1 codes for a transcriptional repressor that is known to associate with the tumor susceptibility gene 101. In mice, DMAP1 facilitates preimplantation epigenetic reprogramming functions including DNMT1 methylation and nucleosome remodelling of TIP60-p400. Dmap1 is also involved in maintaining the integrity of DNA during DNA repair.
Rabbit Anti-DMAP1 antibody recognizes human, mouse, rat, canine, and bovine DMAP1.

Synthetic peptide directed towards the N terminal region of human DMAP1

Rabbit Anti-DMAP1 antibody is suitable for western blot applications at a concentration of 2.5 μg/ml.

DMAP1 is a subunit of several, distinct complexes involved in the repression or activation of transcription. The encoded protein can independently repress transcription and is targeted to replication foci throughout S phase by interacting directly with the N-terminus of DNA methyltransferase 1. During late S phase, histone deacetylase 2 is added to this complex, providing a means to deacetylate histones in transcriptionally inactive heterochromatin following replication. The encoded protein is also a component of the nucleosome acetyltransferase of H4 complex and interacts with the transcriptional corepressor tumor susceptibility gene 101 and the pro-apoptotic death-associated protein 6, among others. Alternatively spliced transcript variants encoding the same protein have been described.This gene encodes a subunit of several, distinct complexes involved in the repression or activation of transcription. The encoded protein can independently repress transcription and is targeted to replication foci throughout S phase by interacting directly with the N-terminus of DNA methyltransferase 1. During late S phase, histone deacetylase 2 is added to this complex, providing a means to deacetylate histones in transcriptionally inactive heterochromatin following replication. The encoded protein is also a component of the nucleosome acetyltransferase of H4 complex and interacts with the transcriptional corepressor tumor susceptibility gene 101 and the pro-apoptotic death-associated protein 6, among others. Alternatively spliced transcript variants encoding the same protein have been described.

Synthetic peptide located within the following region: MATGADVRDILELGGPEGDAASGTISKKDIINPDKKKSKKSSETLTFKRP

Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

rabbit

100

unconjugated

IgG fraction of antiserum

primary antibodies

polyclonal

buffered aqueous solution

53 kDa

horse, human, rat, dog, mouse, guinea pig, rabbit, bovine

0.5 mg - 1 mg/mL

immunohistochemistry: suitable
western blot: suitable

NP_001029195

Q9NPF5

wet ice

−20℃

human ... DMAP1(55929)

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12 - Non Combustible Liquids

WGK 1