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Anti-DYRK1A (N-terminal) antibody produced in rabbit
| 产品编号： | 3358856 |
| 规格： | ~1.5 mg/mL, affinity isolated antibody, buffered aqueous solution |
| 包装规格： | 200 μL |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品别名
Anti-DYRK1A (N-terminal) antibody produced in rabbit
Anti-MBN/MNBH
Anti-Minibrain Drosophila homolog
Anti-MNB protein kinase
Anti-Dual-specificity tyrosine-phosphorylation-regulated kinase 1A
基本信息
| NACRES | NA.41 |
| General description【一般描述】 | DYRK1A (dual-specificity tyrosine-phosphorylated regulated kinase 1A) is a member of a growing family of Ser/Thr protein kinases termed DYRKs. The human and rodent DYRK1A are ubiquitously expressed in adult and fetal tissue with high expression in the brain and heart during development. |
| Application【应用】 | Anti-DYRK1A (N-terminal) antibody produced in rabbit has been used in immunoblotting and immunohistochemistry. |
| Biochem/physiol Actions【生化/生理作用】 | DYRK1A is encoded by a gene located within the Down syndrome (DS) critical region on human chromosome 21 and its expression is found to be elevated in individuals with DS. It might be one of the genes involved in some of the neurological abnormalities observed in DS. It phosphorylates several substrates including transcription factor FKHR, NFAT, STAT3, microtubule-associated protein Tau, glycogen synthase and c-AMP-response element-binding protein. |
| Physical form【外形】 | Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide. |
产品性质
| biological source【生物来源】 | rabbit |
| Quality Level【质量水平】 | 200 |
| conjugate【偶联物】 | unconjugated |
| antibody form【抗体形式】 | affinity isolated antibody |
| antibody product type | primary antibodies |
| clone【克隆】 | polyclonal |
| form【形式】 | buffered aqueous solution |
| mol wt【分子量】 | antigen ~86 kDa |
| species reactivity | rat, mouse, human |
| concentration【浓度】 | ~1.5 mg/mL |
| technique(s) | western blot: 1.5-3 μg/mL using rat brain embryonic extract (S1 fraction) western blot: 3-5 μg/mL using PC12 cell lyste |
| UniProt accession no.【UniProt登记号】 | Q13627 |
| shipped in【运输】 | dry ice |
| storage temp.【储存温度】 | −20℃ |
| Gene Information | human ... DYRK1A(1859) mouse ... Dyrk1a(13548) rat ... Dyrk1a(25255) |
产品说明
| Target description【目标描述】 | DYRK1A (N-terminal) encodes a member of the Dual-specificity tyrosine phosphorylation-regulated kinase (DYRK) family. This member contains a nuclear targeting signal sequence, a protein kinase domain, a leucine zipper motif, and a highly conservative 13-c |
| Disclaimer【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
安全信息
| Storage Class Code【储存分类代码】 | 12 - Non Combustible Liquids |
| Personal Protective Equipment【个人防护装备】 | Eyeshields, Gloves |
