Anti-ELF3 antibody produced in rabbit

NA.41

ELF3 is known to regulate light signaling to the circadian clock. It is also known to function as an epithelial-specific transcription factor.
Rabbit Anti-ELF3 antibody recognizes human, canine, mouse, rat, and bovine ELF3.

Synthetic peptide directed towards the middle region of human ELF3

Rabbit Anti-ELF3 antibody can be used for western blot applications at 2.5μg/ml.

ELF3 is a novel, highly tissue-restricted member of the ets transcription factor/oncogene family. ELF3 contains two putative DNA binding domains: an ETS domain, which is unique in that the 5′ half shows relatively weak homology to known ets factors, and an A/T hook domain, found in HMG proteins and various other nuclear factors. In contrast to any known ets factors, ELF3 is expressed exclusively in epithelial cells. ELF3 is expected to be a critical regulator of epithelial cell differentiation. ETS factor ELF3 is a transcriptional regulator of angiopoietin-1 gene regulation in the setting of inflammation. ELF3 overexpressed early during human breast tumorigenesis. ELF3 expression confers a transformed and in vitro metastatic phenotype to otherwise normal MCF-12A cells. ELF3 mediates the expression of TGF-beta RII, and the transcriptional inhibition of ets-related transcription factor could be a one of the mechanisms of colonic carcinogenesis. ELF3 is positively and negatively modulated by other interacting proteins including Ku70, Ku86, p300, and CBP.

Synthetic peptide located within the following region: PGSCGAGAPSPGSSDVSTAGTGASRSSHSSDSGGSDVDLDPTDGKLFPSD

Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

rabbit

100

unconjugated

IgG fraction of antiserum

primary antibodies

polyclonal

buffered aqueous solution

41 kDa

horse, rabbit, rat, human

0.5 mg - 1 mg/mL

western blot: suitable

NP_001107781

P78545

wet ice

−20℃

human ... ELF3(1999)

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