Anti-FGFR4 antibody produced in rabbit

NA.41

FGFR4 is a member of the fibroblast growth factor receptor family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. Although alternative splicing has been observed, there is no evidence that the C-terminal half of the IgIII domain of this protein varies between three alternate forms, as indicated for family members 1-3. This particular family member preferentially binds acidic fibroblast growth factor and, although its specific function is unknown, it is overexpressed in gynecological tumor samples, suggesting a role in breast and ovarian tumorigenesis.

FGFR4 ()
This antibody is generated from rabbits immunized with recombinant human FGFR4 protein.

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.

rabbit

100

unconjugated

saturated ammonium sulfate (SAS) precipitated

primary antibodies

polyclonal

buffered aqueous solution

human

indirect ELISA: 1:1000
western blot: 1:100-1:500

NP_002002

P22455

dry ice

−20℃

human ... FGFR4(2264)

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12 - Non Combustible Liquids

nwg