Anti-FRS2 (SNT-1) antibody produced in rabbit

MFCD03791556

NA.41

Fibroblast growth factor receptor substrate 2 (FRS2), also known as suc-1 associated neurotrophic factor target protein (SNT) exist in two structurally similar forms namely, FRS2a (SNT-1) and FRS-2b (SNT-2). FRS2 is characterized with a consensus myristylation sequence, involved in its recruitment to the cell membrane 4 and a putative phosphotyrosine binding (PTB) domain in its amino-terminus.

synthetic peptide corresponding to human FRS2 sequence, (amino acids 487-505). The corresponding sequence is identical in Xenopus and differs from the respective human and mouse FRS2β sequences by 2 and 3 amino acids, respectively.

Fibroblast growth factors (FGF) receptor substrate (FRS) functions as a lipid-anchored docking protein that is tyrosine phosphorylated and recruited to FGFR upon FGF stimulation. fibroblast growth factor receptor substrate 2 (FRS2) plays an important role in linking fibroblast growth factor (FGF) and nerve growth factor (NGF) with the Ras/ mitogen-activated protein kinases (MAPKs) signaling pathway, thus relaying information from the cell surface to the nucleus. FRS2 proteins are tyrosine phosphorylated in response to activation of the RET receptor, a tyrosine kinase that functions as the signal transducing receptor for the glial cell line-derived neurotrophic factor (GDNF).

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 1% BSA and 15 mM sodium azide.

rabbit

200

unconjugated

affinity isolated antibody

primary antibodies

polyclonal

buffered aqueous solution

antigen 92-95 kDa (doublet)

rat, human, mouse

immunoprecipitation (IP): 10-20 μg using RIPA lysate of mouse NIH/3T3 cells
microarray: suitable
western blot: 1:1,000 using whole cell extracts of rat PC-12 cells or human HepG2 cells

Q8WU20

dry ice

−20℃

human ... FRS2(10818)
mouse ... Frs2(327826)
rat ... Frs2(314850)

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12 - Non Combustible Liquids

WGK 2