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Anti-GABAA Receptor (α1 subunit) antibody produced in rabbit
基本信息
MDL number | MFCD01092338 |
NACRES | NA.41 |
General description【一般描述】 | GABAA and GABAB receptors differ with regard to their ionic characteristics and pharmacological properties. The GABAA receptor is an ionotropic receptor that forms the GABA gated chloride channel and consists of several heterogeneous subunits with membrane recognition sites for benzodiazapenes. |
Immunogen【免疫原】 | peptide corresponding to amino acids 28-43 of rat GABA(A) receptor α1 subunit. |
Application【应用】 | Anti-GABAA Receptor (α1 subunit) antibody produced in rabbit is suitable for detection of GABA-A α1 subunit by immunohistochemistry using rat brain sections and by immunoblotting at a working dilution of 1:400-1:1000 using rat brain membranes. |
Biochem/physiol Actions【生化/生理作用】 | The inhibitory neurotransmitter GABA signals through two distinct types of pre- and postsynaptic receptors, GABAA and GABAB. Both GABA receptors can regulate depression of synaptic transmission and be involved in the inhibition controlling neuronal excitability. α1 is a subtype of GABAA receptor expressed selectively by serotonergic and GABAergic neurons. Serotonergic neurons express strong α3 immunoreactivity but, do not show any α1 immunoreactivity. On the contrary, GABAergic neurons express both α1 and α3 subunits. |
Physical form【外形】 | Lyophilized from phosphate buffered saline, pH 7.4, containing 1% bovine serum albumin, and 0.05% sodium azide. |
Preparation Note【制备说明】 | Reconstitute the 0.05 mL vial with 50 μL deionized water. Reconstitute the 0.2 mL vial with 0.2 mL deionized water. After reconstitution, the antibody concentration is ~0.8 mg/mL. |
产品性质
biological source【生物来源】 | rabbit |
Quality Level【质量水平】 | 100 |
conjugate【偶联物】 | unconjugated |
antibody form【抗体形式】 | affinity isolated antibody |
antibody product type | primary antibodies |
clone【克隆】 | polyclonal |
form【形式】 | lyophilized powder |
mol wt【分子量】 | antigen ~50 kDa |
species reactivity | rat, bovine (predicted), mouse, chicken (predicted), human (predicted) |
technique(s) | immunohistochemistry: suitable using rat brain sections western blot: 1:400-1:1,000 using rat brain membranes |
UniProt accession no.【UniProt登记号】 | P14867 |
storage temp.【储存温度】 | −20℃ |
Gene Information | human ... GABRA1(2554) mouse ... Gabra1(14394) rat ... Gabra1(29705) |
产品说明
Disclaimer【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
安全信息
Storage Class Code【储存分类代码】 | 12 - Non Combustible Liquids |
WGK | WGK 2 |