Anti-GABA_A Receptor (α4 subunit), N-Terminus antibody produced in rabbit

MFCD07370319

NA.41

Gamma-aminobutyric acid (GABA) receptor is the multifunctional, pentameric membrane proteins that operate GABA-gated chloride channels. It acts as major inhibitory neurotransmitter in the adult mammalian brain. It is a member of the neurotransmitter ligand-gated ion channels which plays various functions in the central nervous system, the peripheral nervous system, and in some non-neuronal tissues. At least four types of subunits (α, β, γ and δ) of GABA have been identified. Generally it contains one type of α and β subunit, and a single γ polypeptide in a ratio of 2:2:1.

synthetic peptide from the N-terminus of the rat GABA_A receptor α4 subunit.

Anti-GABA_A Receptor (α4 subunit), N-Terminus antibody is suitable for immunoprecipitation and western blot at a dilution of 1:1,000-1:2,000 using rat brain lysate.

GABA is synthesized primarily from glutamate by glutamate decarboxylase (GAD). It is triggered by binding to its ligand-gated chloride channels, GABA(A) and GABA(C) as well as metabotropic receptor GABA(B). Along with neural development, it is also involved in a wide variety of physiological functions in tissues and organs outside the brain.

Solution in 10 mM HEPES, pH 7.5, 150 mM NaCl, 100 μg/mL BSA and 50% glycerol.

rabbit

200

unconjugated

affinity isolated antibody

primary antibodies

polyclonal

buffered aqueous glycerol solution

sufficient for 10 blots

antigen (active form) ~64 kDa

rat

immunoprecipitation (IP): suitable
western blot: 1:1,000-1:2,000 using rat brain lysate

P28471

wet ice

−20℃

rat ... Gabra4(140675)