Anti-GH2 antibody produced in rabbit

NA.41

Growth hormone 2 (GH-V), a member of the growth hormone/placental lactogen (GH/PL) gene cluster, is an isoform of growth hormone produce mainly in the placenta as opposed to the pituitary expressed GH-N. Both GH-V and GH-N interact, differentially, with the two growth hormone receptors.

Anti-GH2 polyclonal antibody reacts with human, mouse, rat, rabbit growth hormone-2 (GH-V) proteins.

Synthetic peptide directed towards the middle region of human GH2

Anti-GH2 polyclonal antibody is used to tag growth hormone-2 (GH-V) proteins for detection and quantitation by Western blotting and in cells and tissues by immunohistochemical (IHC) techniques. It is used as a probe to study the differential roles of growth hormone-2 (GH-V) versus GH-N at the level of growth-hormone binding and function within tissues.

GH2 is a member of the somatotropin/prolactin family of hormones which play an important role in growth control. Mutations in its gene lead to placental growth hormone/lactogen deficiency.The protein encoded by this gene is a member of the somatotropin/prolactin family of hormones which play an important role in growth control. The gene, along with four other related genes, is located at the growth hormone locus on chromosome 17 where they are interspersed in the same transcriptional orientation; an arrangement which is thought to have evolved by a series of gene duplications. The five genes share a remarkably high degree of sequence identity. Alternative splicing generates additional isoforms of each of the five growth hormones, leading to further diversity and potential for specialization. As in the case of its pituitary counterpart, growth hormone 1, the predominant isoform of this particular family member shows similar somatogenic activity, with reduced lactogenic activity. Mutations in this gene lead to placental growth hormone/lactogen deficiency.

Synthetic peptide located within the following region: NQSYSKFDTKSHNDDALLKNYGLLYCFRKDMDKVETFLRIVQCRSVEGSC

Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

rabbit

100

unconjugated

IgG fraction of antiserum

primary antibodies

polyclonal

buffered aqueous solution

22 kDa

mouse, sheep, horse, goat, human, pig, bovine, rat, rabbit

0.5 mg - 1 mg/mL

western blot: suitable

NP_072050

O14643

wet ice

−20℃

human ... GH2(2689)

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