Anti-Glutamate Receptor 4, Metabotropic antibody produced in rabbit

MFCD02096869

NA.41

synthetic peptide corresponding to the N-terminal extracellular domain of human metabotropic glutamate receptor 4, conjugated to KLH. The immunizing peptide has 100% homology with the rat gene and 89% homology with the mouse gene.

Anti-Glutamate Receptor 4, Metabotropic antibody is suitable for immunohistochemistry (formalin-fixed, paraffin-embedded sections) at a concentration of 3μg/mL using human neurons, cortex.

Glutamate, the excitatory neurotransmitter, is involved in fast excitatory synaptic transmission. It acts on ligand-gated receptor channels, termed NMDA, AMPA and kainate receptors. The metabotropic form consist of eight subtypes (mGluR1-8) divided into three groups (I-III). Group I binds to phospholipase C and intracellular calcium mobilization, whereas both groups II and III inhibit adenyl cyclase. The metabotropic receptors have some therapeutic potentials. group I receptors have been implicated in post-ischemic neuronal injury, and antagonists of group I appear to have a neuroprotective effect.

Solution in phosphate buffered saline, pH 7.7, containing 0.01% sodium azide.

rabbit

200

unconjugated

affinity isolated antibody

primary antibodies

polyclonal

buffered aqueous solution

human

not available in Japan

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 3 μg/mL using human neurons, cortex

Q14833

dry ice

−20℃

human ... GRM4(2914)
mouse ... Grm4(268934)
rat ... Grm4(24417)

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12 - Non Combustible Liquids

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